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首页> 外文期刊>African Journal of Biotechnology >Induction of protective immunity against toxoplasmosis in mice by immunization with a plasmid encoding Toxoplama gondii ROP1 gene
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Induction of protective immunity against toxoplasmosis in mice by immunization with a plasmid encoding Toxoplama gondii ROP1 gene

机译：用弓形虫ROP1基因编码的质粒免疫诱导小鼠抗弓形虫病

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摘要

Toxoplasma gondii?is an obligate intracellular protozoan that is a causative agent of toxoplasmosis, a disease which may result in a spectrum of consequences. It has been shown that DNA vaccine can be effective in partial protection against this parasite. In the present work, a single DNA vaccine containing ROP1 was evaluated against?T. gondii?infection in Balb/c mice. To enhance the immune response, alum was used as an adjuvant. After intramuscular immunization, cytokine and antibody assays and mortality rate were evaluated. The results showed that mice immunized by pcROP1 with or without alum produced high Th1 immune response compared with control groups. This type of DNA vaccine prolonged slightly the survival time. The current study showed that ROP1 DNA vaccine can induced partial protective response against toxoplasmosis.
机译：弓形虫是专性的胞内原生动物，是弓形虫病的病原体，这种疾病可能会导致一系列后果。已经表明，DNA疫苗可以有效地部分保护该寄生虫。在目前的工作中，针对ΔT评估了包含ROP1的单一DNA疫苗。在Balb / c小鼠中感染了弓形虫。为了增强免疫应答，明矾被用作佐剂。肌内免疫后，评估细胞因子和抗体测定以及死亡率。结果显示，与对照组相比，有或没有明矾的pcROP1免疫的小鼠均产生高Th1免疫应答。这种类型的DNA疫苗略微延长了生存时间。目前的研究表明，ROP1 DNA疫苗可以诱导针对弓形虫病的部分保护性反应。

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