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首页> 外文期刊>African Journal of Biotechnology >Effect of quercetin nanoparticles on the kidney of the streptozotocin-induced diabetes in male rats: A histological study and serum biochemical alterations
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Effect of quercetin nanoparticles on the kidney of the streptozotocin-induced diabetes in male rats: A histological study and serum biochemical alterations

机译：槲皮素纳米颗粒对链脲佐菌素诱发的糖尿病大鼠肾脏的组织学研究和血清生化改变

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摘要

Diabetes is directly involved in oxidative stress production. Therefore, this study was conducted to investigate the morphological and functional alterations caused by oxidative stress and to evaluate the antioxidant effect of quercetin nanoparticles (QUNPs) in streptozotocin (STZ)-induced diabetic (type II) rats. Seventy two male albino adult rats were randomly distributed in 6 different experimental groups, with 12 animals per group: Normal Control (NC) group, Positive Control (PC) group received one dose of STZ (60 mg/kg body weight [bw]); QUNPs 10 mg/kg bw/day alone group; QUNPs 10 mg/kg bw/day + one dose of STZ (60 mg/kg bw) group; QUNPs 20 mg/kg bw/day alone group; and QUNPs 20 mg/kg bw/day + one dose of STZ (60 mg/kg bw) group. STZ-diabetic rats were treated with QUNPs (10 and 20 mg/kg bw/day) for 7 weeks to analyze their effects on markers of renal enzymes antioxidant [malondialdehyde (MDA), catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx)], total protein and albumin, and also on kidney tissues. The results showed that the particle size of QUNPs is 16.13 nm at flow rate 10 ml/min. QUNPs especially at the dosage of 20 mg/kg bw/day gave results close to normal values observed in NC compared to PC. Also, histopathology of kidney sections for QUNPs 20 mg/kg bw/day + STZ and QUNPs (10 and 20 mg/kg bw/day) alone, appeared similar to NC. It can be concluded that QUNPs could become a promising adjuvant in the treatment of diabetes mellitus and can act as an antioxidant agent.
机译：糖尿病直接参与氧化应激的产生。因此，本研究旨在研究氧化应激引起的形态和功能改变，并评估槲皮素纳米颗粒（QUNP）在链脲佐菌素（STZ）诱导的糖尿病（II型）大鼠中的抗氧化作用。将72只雄性白化病成年大鼠随机分为6个不同的实验组，每组12只动物：正常对照组（NC），阳性对照组（PC）组接受一剂STZ（60 mg / kg体重[bw]） ; QUNPs每天10 mg / kg bw /天组; QUNPs 10 mg / kg bw /天+一剂STZ（60 mg / kg bw）组; QUNPs每天20 mg / kg bw /天组;和QUNPs 20 mg / kg bw /天+一剂STZ（60 mg / kg bw）组。对STZ糖尿病大鼠用QUNPs（10和20 mg / kg bw /天）治疗7周，以分析其对肾酶抗氧化剂[丙二醛（MDA），过氧化氢酶（CAT），谷胱甘肽还原酶（GR）和谷胱甘肽过氧化物酶（GPx）]，总蛋白和白蛋白以及肾脏组织。结果表明，在流速为10 ml / min时，QUNPs的粒径为16.13 nm。与PC相比，尤其是在每天20 mg / kg bw /天的剂量下，QUINP的结果接近于NC中观察到的正常值。同样，单独使用20 mg / kg bw /天的QUNPs + STZ和QUNPs（10和20 mg / kg bw /天）的肾脏切片的组织病理学表现与NC相似。可以得出结论，QUNPs可以成为治疗糖尿病的有希望的佐剂，并可以作为抗氧化剂。

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