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Commensal Staphylococcus spp., Acinetobacter spp. and Stenotrophomonas maltophilia as reservoirs of antibiotic resistance genes

机译:共生葡萄球菌属,不动杆菌属。和嗜麦芽窄食单胞菌作为抗生素抗性基因的贮藏库

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Staphylococcus?species,?Acinetobacter?species and?Stenotrophomonas maltophiliaare of particular importance as they sometimes reside as flora on the intact skin and nasal passages of man and farm animals. Studies around the globe have shown them as “friends and foes” especially in immunocompromised individuals as they occur as commensals but sometimes as pathogens that infect, causing morbidity and consequently higher therapeutic cost. The occurrence of antibiotic resistance gene(s) in their genomes and their phenotypic display of resistance make them difficult to control and places a high demand on the assessment of such genes in the bacteria. In doing this, the less considered (commensals) have been described more recently as a reservoir for antibiotic resistance genes. The transfer of heavy metal and antibiotic resistance genes from?Staphylococcus?spp., a Gram positive bacterium toS. maltophilia?and?Acinetobacter?species, Gram negative bacteria confer the resilience to control measures that is peculiar with the former on the latter. This attribute in?Acinetobacter?spp. and?S. maltophilia?have encouraged their inclusion in drug screening research. Intermittent assessment of resistance genes in the ecosystem should be embraced to foster appropriate measures against their spread.?Key word:?Commensal, resistance genes,?Staphylococcus, Acinetobacter, Stenotrophomonas maltophilia.
机译:葡萄球菌,不动杆菌属和嗜麦芽窄食单胞菌特别重要,因为它们有时作为人和动物的完整皮肤和鼻道中的菌群而存在。全球研究表明,它们是“朋友和敌人”,特别是在免疫功能低下的个体中,因为它们以礼貌出现,但有时以感染的病原体出现,从而导致发病率并因此提高了治疗成本。抗生素抗性基因在其基因组中的出现及其抗性的表型显示使其难以控制,并且对细菌中此类基因的评估提出了很高的要求。在此过程中,较不被考虑的(常识)最近被描述为抗生素抗性基因的储存库。从革兰氏阳性菌?Staphylococcus?spp。向S转移重金属和抗生素抗性基因。革兰氏阴性细菌赋予了对适应性的控制力,而后者是前者所特有的。此属性在不动杆菌属中。和?嗜麦芽热症鼓励他们将其纳入药物筛选研究。应当对生态系统中的抗性基因进行间歇性评估,以采取适当措施来防止其扩散。关键词:常见,抗性基因,葡萄球菌,不动杆菌,嗜麦芽单胞菌。

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