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首页> 外文期刊>African Journal of Biotechnology >In vitro antitumor activity of Gracilaria corticata (a red alga) against Jurkat and molt-4 human cancer cell lines
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In vitro antitumor activity of Gracilaria corticata (a red alga) against Jurkat and molt-4 human cancer cell lines

机译：Gracilaria corticata（红藻）对Jurkat和Molt-4人癌细胞系的体外抗肿瘤活性

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摘要

Gracilaria corticata?is a red alga which can be collected from many sea coasts around the world such as China, India, Persian Gulf, etc. The Persian Gulf is a unique marine habitat infested with diverse seaweeds. The aim of the present study is to explore anticancer potential of the crude extracts from?G. corticata?which was collected from the Bushehr coast (South west of Iran). Here, different concentration of the aqueous extract from?G. corticata?was tested for probable antitumoral activity on Jurkat and molt-4 human lymphoblastic leukemic cell lines. The cells were treated by different concentration of algal extract and the number of viable cells was determined by trypan blue. Also, cytotoxicity of the extract was evaluated by methyl thiazolyl tetrazolium (MTT) assay. The results showed that 9.336 and 9.726 μg/μl of algal extract were the most effective concentrations against Jurkat and molt-4 cells, respectively. The water crude extract of red alga?G. corticata?had significant anticancer activity and it might be a good candidate for further investigations in order to develop a natural compound as an anticancer agent which can be used for the production of potential anticancer drug and novel pharmaceutical leads.
机译：Gracilaria corticata？是一种红藻，可以从世界许多沿海地区采集，例如中国，印度，波斯湾等。波斯湾是独特的海洋栖息地，充满了各种海藻。本研究的目的是探索？G粗提物的抗癌潜力。 corticata？是从Bushehr海岸（伊朗西南部）收集的。在此，不同浓度的ΔG的水提取物。测试了皮质糖对Jurkat和Molt-4人淋巴母细胞性白血病细胞系的可能抗肿瘤活性。用不同浓度的藻提取物处理细胞，并用锥虫蓝测定活细胞的数目。另外，提取物的细胞毒性通过甲基噻唑基四唑鎓（MTT）测定法进行评估。结果显示，藻提取物的9.336和9.726μg/μl分别对Jurkat和molt-4细胞最有效。红藻水的粗提物。皮质类药物具有显着的抗癌活性，为开发一种天然化合物作为抗癌剂，可用于生产潜在的抗癌药和新型药物，它可能是进行进一步研究的良好选择。

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