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首页> 外文期刊>African Journal of Biotechnology >The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves
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The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves

机译：樟子松叶片二氯甲烷粗提物的抗氧化性能，细胞毒性和单胺氧化酶抑制能力

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摘要

Tarchonanthus camphoratus?(camphor bush) has been widely used for numerous medicinal purposes. The aim of the present study was to evaluate the antioxidant properties, cytotoxicity and monoamine oxidase inhibition activities of the crude dichloromethane leaf extract of?T. camphoratus.?The antioxidant activities were assessed using the thiobarbituric acid-reactive substances (TBARS) assay and the nitroblue tetrazolium (NBT) assay.?The cytotoxicity assays were performed according to the microculture MTT method.?From the MTT assay,?it was determined that at a concentration of 10 mg/ml of crude extract, 95% of the neuroblastoma cells were killed. Almost 99% of the cells were viable at a concentration of 0.08 mg/ml extract. The extract also showed the ability to inhibit monoamine oxidase (MAO-A and MAO-B) with the corresponding inhibitory concentration, IC50?values of 1.371 and 0.2737 mg/ml, respectively. The antioxidant activity and cytotoxic effect of the extracts increased with increase in concentration. This study suggests that the dichloromethane leave extract of?T. camphoratus?can potentially be used as a readily accessible source of natural antioxidants.
机译：Tarchonanthus camphoratus？（樟树丛）已被广泛用于许多医学目的。本研究的目的是评估ΔT的粗制二氯甲烷叶提取物的抗氧化性能，细胞毒性和单胺氧化酶抑制活性。使用硫代巴比妥酸反应性物质（TBARS）测定和硝基蓝四唑（NBT）测定抗氧化活性。根据微培养MTT方法进行细胞毒性测定。结果表明，以10 mg / ml的粗提液浓度杀死了95％的神经母细胞瘤细胞。几乎99％的细胞以0.08 mg / ml的提取物浓度存活。提取物还显示出抑制单胺氧化酶（MAO-A和MAO-B）的能力，相应的抑制浓度分别为1.371和0.2737 mg / ml，IC50值。提取物的抗氧化活性和细胞毒性作用随浓度的增加而增加。这项研究表明，二氯甲烷会留下ΔT的提取物。樟脑可潜在地用作天然抗氧化剂的容易获得的来源。

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