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首页> 外文期刊>African Journal of Biotechnology >Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc
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Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc

机译：甲硫磷诱导的大鼠血液，生化和肝组织学改变：硒和锌的改善作用

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The aim of this study was to determine the effect of a sub-acute 4-week exposure to methidathion (MD) on the hematological system and hepatic integrity of rats. We also assessed whether co-administration of micronutrients such as selenium (Se) and zinc (Zn) prevented MD-induced hepatic damage. Rats were randomly divided into four groups of six each: the first group served as a control which received standard diet, the second group received both Se (0.5mg/kg of diet) and Zn (0.227 g/l drinking water), the third group received only MD (5 mg/kg b.w. by gavage using corn oil as a vehicle), and the fourth group received MD and combined selenium and zinc. After four weeks, exposure to MD induced a significant increase in plasmatic activities of AST, ALT, ALP, LDH, and liver malondialdehyde level. In contrast, reduced glutathione level (GSH), and the activities of catalase (CAT), superoxide dismutase (SOD), and the glutathione peroxidase (GPx) content of hepatic tissue decreased significantly. Moreover, treatment with Se and Zn in MD-treated rats maintained all the biochemical parameters cited above. In conclusion, the obtained results indicate the ability of Se and Zn to attenuate the MD-induced liver and erythrocytes oxidative damage.
机译：这项研究的目的是确定亚甲基硫磷（MD）亚急性4周暴露对大鼠血液系统和肝完整性的影响。我们还评估了微量营养素（如硒（Se）和锌（Zn））的共同施用是否可以预防MD引起的肝损害。大鼠随机分为四组，每组六只：第一组作为对照组，接受标准饮食，第二组同时接受硒（0.5mg / kg饮食）和锌（0.227g / l饮用水），第三组第一组仅接受MD（以玉米油为媒介的强饲法，体重为5 mg / kg bw），第四组接受MD以及硒和锌的组合。四周后，接触MD会导致AST，ALT，ALP，LDH和肝脏丙二醛水平的血浆活性显着增加。相反，肝组织中的谷胱甘肽水平（GSH）降低，过氧化氢酶（CAT），超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的活性明显降低。此外，在MD治疗的大鼠中用Se和Zn进行的治疗保持了上述所有生化参数。总之，获得的结果表明硒和锌具有减轻MD诱导的肝脏和红细胞氧化损伤的能力。

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