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首页> 外文期刊>African Journal of Biotechnology >Clinical significance of RECK and MMP-9 expression in cutaneous squamous cell carcinoma
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Clinical significance of RECK and MMP-9 expression in cutaneous squamous cell carcinoma

机译：RECK和MMP-9在皮肤鳞状细胞癌中表达的临床意义

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Matrix metalloproteinase 9 (MMP-9) is recognized for its ability to promote tumor invasion and metastasis. However, its role and that of a novel regulator of MMP-9, reversion-inducing-cysteine-rich protein with kazal motifs (RECK), have not been explored in cutaneous squamous cell carcinoma (SCC). We investigated expression of MMP-9 and RECK in SCC to determine the clinical significance of their expression and potential uses for diagnostic, prognostic and therapeutic approaches. Immunohistochemistry was used to analyze expression in?36?SCC?and 13 healthy skin samples collected at our hospital. RECK expression was detected in 33.3% of SCC samples, significantly fewer?than for control samples (84.6%,?P<0.05). In contrast,?MMP-9 was expressed in 77.8% of SCC samples, significantly more?than in control samples?(30.8%,?P<0.05). RECK and MMP-9 expression in SCC samples were negatively correlated (r?= -0.406,?P<0.05). Furthermore, negative RECK and positive MMP-9 expression in?SCC tissues?were correlated with differentiation degree and lymph node metastasis (P<0.05) but not with gender or age. Thus, low/absent expression of RECK and increased expression of MMP-9 correspond to increased disease severity. These proteins may play opposing roles in pathogenesis of SCC and may serve as future diagnostic or prognostic markers. Therefore RECK should be further investigated for therapeutic potential as an MMP-9 inhibitor.
机译：基质金属蛋白酶9（MMP-9）被认为具有促进肿瘤侵袭和转移的能力。然而，尚未在皮肤鳞状细胞癌（SCC）中探索其作用和新型的MMP-9调节剂，即具有kazal基序的回复诱导型富含半胱氨酸的蛋白质（RECK）。我们调查了SMP中MMP-9和RECK的表达，以确定其表达的临床意义以及其在诊断，预后和治疗方法中的潜在用途。免疫组织化学分析了我院收集的36例SCC和13例健康皮肤样本中的表达。在33.3％的SCC样品中检测到RECK表达，显着低于对照样品（84.6％，ΔP<0.05）。相反，在77.8％的SCC样品中表达了“ MMP-9”，比对照样品中的表达高得多（30.8％，P <0.05）。 SCC样品中RECK和MMP-9的表达呈负相关（r = -0.406，△P <0.05）。此外，SCC组织中RECK阴性和MMP-9阳性表达与分化程度和淋巴结转移相关（P <0.05），而与性别或年龄无关。因此，RECK的低/缺乏表达和MMP-9的表达增加对应于疾病严重程度的增加。这些蛋白质可能在SCC的发病机理中起相反的作用，并可能用作未来的诊断或预后标志物。因此，应进一步研究RECK作为MMP-9抑制剂的治疗潜力。

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