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Glutathione role in gallium induced toxicity

机译：谷胱甘肽在镓诱导的毒性中的作用

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Metallo-elements have strong affinity for sulfhydryl group (-SH) of glutathione (GSH) present in tissues. It is very important and interesting to study the reaction of gallium nitrate and glutathione as biomarker of glutathione role in detoxification and conjugation in whole blood components (plasma and cytosolic fraction). The effect of gallium nitrate different concentrations was examined on GSH present in whole blood components. Decrease in GSH level was dependant on gallium nitrate concentration. The decrease in GSH level of whole blood components was more prominent with the time of incubation of gallium nitrate. Decrease in the concentration of reduced glutathione may be due to the interaction of reduce glutathione and gallium nitrate to form oxidized glutathione (GSSG) or gallium-glutathione complex. This change in GSH metabolic status provides information regarding the role of GSH in detoxification of gallium nitrate. The effect of gallium metal on glutathione in blood components?wasdiscussed in this?study?in?in vitro?condition as a model for?in vivo?condition.
机译：金属元素对组织中存在的谷胱甘肽（GSH）的巯基（-SH）具有很强的亲和力。研究硝酸镓和谷胱甘肽的反应作为谷胱甘肽在全血成分（血浆和胞浆级分）的解毒和结合中的作用的重要标志物，非常重要和有趣。检查了不同浓度的硝酸镓对全血成分中GSH的影响。 GSH水平的降低取决于硝酸镓的浓度。随着硝酸镓的培养时间的增加，全血成分的谷胱甘肽水平下降更为明显。还原型谷胱甘肽浓度降低可能是由于还原型谷胱甘肽与硝酸镓相互作用形成氧化型谷胱甘肽（GSSG）或镓-谷胱甘肽复合物。 GSH代谢状态的这种变化提供了有关GSH在硝酸镓排毒中的作用的信息。在该“体外条件”研究中讨论了金属镓对血液成分中谷胱甘肽的影响，以此作为“体内条件”的模型。

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