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首页> 外文期刊>African Journal of Biotechnology >Theoretical evaluations of electro-manipulation from Jurkat T cells exposed to pulsed electric fields (PEFs) with different time durations
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Theoretical evaluations of electro-manipulation from Jurkat T cells exposed to pulsed electric fields (PEFs) with different time durations

机译：暴露于不同持续时间的脉冲电场（PEF）的Jurkat T细胞进行电操纵的理论评估

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The multilayer dielectric sphere model (MDSM) was used to analyze responses of Jurkat T cells to pulsed electric fields (PEFs). The dependence of voltages across nuclear plasma, nuclear envelope, cytoplasm and plasma membrane on different time durations of PEFs was calculated by employing the inverse laplace transformation (ILT) in time domain with Maple software. Cytochrome C release was considered as a secondary effect of PEFs when mitochondria substructures were taken into account. It is proposed that two-step process of Cytochrome C release can be realized by bioelectric impulse effect on mitochondria.?Keywords:?Laplace transformation, Jurkat T, pulsed electric fields (PEFS), cytochrome C.
机译：多层介电球模型（MDSM）用于分析Jurkat T细胞对脉冲电场（PEF）的响应。通过使用Maple软件在时域中进行拉普拉斯逆变换（ILT），计算了PEF的不同持续时间对核血浆，核包膜，细胞质和质膜的电压依赖性。当考虑到线粒体亚结构时，细胞色素C的释放被认为是PEF的次要作用。提出通过生物电对线粒体的脉冲效应可以实现细胞色素C释放的两步过程。关键词：拉普拉斯变换，Jurkat T，脉冲电场（PEFS），细胞色素C

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