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首页> 外文期刊>African Journal of Biotechnology >Production and characterization of antimicrobial active substance from some macroalgae collected from Abu-Qir bay (Alexandria) Egypt
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Production and characterization of antimicrobial active substance from some macroalgae collected from Abu-Qir bay (Alexandria) Egypt

机译：从埃及阿布奇尔湾（亚历山大）采集的一些大型藻类中生产抗菌活性物质并进行表征

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The antimicrobial activity of three different macroalgal species [Jania rubens (Linnaeus) Lamouroux; Ulva fasciata Delile and Sargassum vulgare C. Agardh] belonging to Rhodophyta, Chlorophyta and Phaeophyceae, respectively, were collected seasonally in 2007 to 2008 from Abu-Qir bay (Alexandria, Egypt). The different macroalgal species were tested against pathogenic microbes such as Bacillus subtilis, Staphylococcus aureus and Streptococcus aureus as gram-positive bacteria, Escherichia coli, Salmonella typhi and Klebsiella pneumoniae as gram-negative bacteria and one yeast strain, Candida albicans. The influence of sampling season on the antimicrobial activity of the collected seaweeds showed strong activity in spring followed by winter, summer and autumn, respectively. However, the strongest antimicrobial activity was recorded in 70% acetone extract of U. fasciata collected during winter against all the tested microorganisms. This extract was purified using column chromatography (CC) and thin layer chromatography (TLC). The nature of this purified antimicrobial material was detected using different chemical analysis (UV, IR,1H NMR and MS) which indicated that it is an aromatic compound and has different active groups (-NH2, -C=O, -NO2, phenyl ring and -CH3). The molecular weight of the compound was determined (662) and its structure was characterized as a derivative of phthalate ester [(E)-1-(10-acetamido-2-nitrodec-9-enyl) 2-(10-acetamido-2-nitrodecyl) 4-methylphthalate]. This is the first evidence of the isolation of phthalate esters derivative from green seaweeds (U. fasciata) that has broad antimicrobial activity.
机译：三种不同的大型藻类[Jania rubens（Linnaeus）Lamouroux;分别属于红藻类，绿藻类和藻类科的Ulva fasciata Delile和Sargassum vulgare C. Agardh在2007年至2008年间季节性采集自阿布奇尔湾（埃及亚历山大）。测试了不同的大藻物种对诸如革兰氏阳性细菌的枯草芽孢杆菌，金黄色葡萄球菌和金黄色链球菌等致病微生物，作为革兰氏阴性细菌的大肠杆菌，鼠伤寒沙门氏菌和肺炎克雷伯菌以及一种酵母菌株白色念珠菌的致病性微生物。采样季节对所收集海藻抗菌活性的影响在春季依次为强活性，其次是冬季，夏季和秋季。但是，在冬季收集到的全部筋膜丙酮的70％丙酮提取物中，对所有测试的微生物均表现出最强的抗菌活性。使用柱色谱法（CC）和薄层色谱法（TLC）纯化该提取物。使用不同的化学分析（UV，IR，1H NMR和MS）检测到这种纯化的抗菌材料的性质，这表明它是一种芳香族化合物，具有不同的活性基团（-NH2，-C = O，-NO2，苯环）和-CH3）。测定该化合物的分子量（662），并将其结构表征为邻苯二甲酸酯[（E）-1-（10-乙酰氨基-2-硝基癸-9-烯基）2-（10-乙酰氨基-2）的衍生物-硝基癸基）4-甲基邻苯二甲酸酯]。这是从具有广泛抗菌活性的绿色海藻（U. fasciata）中分离邻苯二甲酸酯衍生物的第一个证据。

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