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Studies on cytotoxic, phytotoxic and volatile profile of the bark extract of the medicinal plant, Mallotus tetracoccus (Roxb.) Kurz.

机译:药用植物四叶青(Mallotus tetracoccus(Roxb。)Kurz)树皮提取物的细胞毒性,植物毒性和挥发性特征的研究。

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This study was aimed at analysing the compounds present in the bark extract of Mallotus tetracoccus (Roxb.) Kurz. by GC-MS analysis and also to investigate the cytotoxic and phytotoxic activity of Mallotus tetracoccus (Roxb.) Kurz. bark extract. The major constituents in M. tetracoccus (Roxb.) Kurz. bark extract are thiocyanic acid and 2-propynyl ester (52.04%). It possesses biocidal, antioxidative, antimutagenic and anticancer activity. The cytotoxic activity of bark extract was evaluated by brine shrimp lethality bioassay method and the LC50 value was found to be 84.72 μg/ml compared to taxol 0.85 μg/ml. Phytotoxicity assay showed significant root length inhibition by the extract at the concentrations of 100, 1000 and 10000 ppm. Similarly, seed germination studies shows that the bark extract possess significant inhibition at concentrations of 1000 and 7500 ppm.
机译:这项研究的目的是分析存在于四叶木槌(Roxb。)Kurz的树皮提取物中的化合物。通过GC-MS分析,还研究了四重木槌(Roxb。)Kurz的细胞毒性和植物毒性活性。树皮提取物。四球菌(Roxb。)库尔兹氏菌的主要成分。树皮提取物是硫氰酸和2-丙炔酸酯(52.04%)。它具有杀菌,抗氧化,抗诱变和抗癌活性。通过盐水虾致死生物测定法评估树皮提取物的细胞毒活性,LC50值为84.72μg/ ml,而紫杉醇为0.85μg/ ml。植物毒性试验显示,在100、1000和10000 ppm的浓度下,提取物均具有明显的根长抑制作用。同样,种子发芽研究表明,树皮提取物在1000和7500 ppm的浓度下具有明显的抑制作用。

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