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首页> 外文期刊>African Journal of Biotechnology >Heterozygote polymorphisms of ARG16GLY and GLN27GLU ADRB2 gene is risk protective for obesity in Javanese population of Indonesia
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Heterozygote polymorphisms of ARG16GLY and GLN27GLU ADRB2 gene is risk protective for obesity in Javanese population of Indonesia

机译：ARG16GLY和GLN27GLU ADRB2基因的杂合子多态性对印度尼西亚爪哇人的肥胖具有风险保护作用

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The relationship between obesity and insulin resistance is influenced by various factors, including genetics. ADRB2 gene polymorphisms of Arg16Gly and Gln27Glu showed inconsistent results toward obesity and insulin resistance in some populations. This study aimed to investigate the frequency of the genetic polymorphisms of Arg16Gly and Gln27Glu of the ADRB2 gene and to analyze risk factors for obesity and insulin resistance in Javanese sample population. This study was conducted on 100 control and 100 obese subjects. Subjects were measured for body weight and height to determine body mass index. Waist hip ratio was calculated by dividing the size of waist circumference by hip circumference. Fasting blood glucose was measured with GOD-PAP methods, and plasma insulin levels was measured using ELISA. Arg16Gly and Gln27Glu ADRB2 gene polymorphisms were detected using the PCR-RFLP method. Results of polymorphisms of Arg16Gly showed that AG genotype decreased the risk of obesity with OR 0.264 (CI 95% : 0.119 – 0.585), p = 0,001 compared to the AA genotype. CG genotype of Gln27Glu increased the risk of obesity with RR 2.082 (CI 95% : 1.786 – 2.427). CC and CG genotypes toward GG genotype in the obese group had significant differences for plasma insulin, but were not significantly different for BMI, waist hip ratio, fasting blood glucose, and HOMA-IR. The combination of Arg16Gly and Gln27Glu AG+CG decreased the risk of obesity compared to AA+GG; however, it was not associated with insulin resistance.
机译：肥胖与胰岛素抵抗之间的关系受多种因素影响，包括遗传因素。某些人群中，Arg16Gly和Gln27Glu的ADRB2基因多态性对肥胖和胰岛素抵抗的结果不一致。本研究旨在调查ADRB2基因Arg16Gly和Gln27Glu遗传多态性的频率，并分析爪哇样本人群中肥胖和胰岛素抵抗的危险因素。这项研究是针对100位对照者和100位肥胖者进行的。测量受试者的体重和身高以确定体重指数。通过将腰围的尺寸除以臀围来计算腰围臀围比。用GOD-PAP法测定空腹血糖，用ELISA法测定血浆胰岛素水平。使用PCR-RFLP方法检测Arg16Gly和Gln27Glu ADRB2基因多态性。 Arg16Gly多态性结果表明，与AA基因型相比，AG基因型降低了肥胖风险，OR为0.264（CI 95％：0.119 – 0.585），p = 0,001。 Gln27Glu的CG基因型增加了患肥胖症的风险，RR 2.082（CI 95％：1.786 – 2.427）。肥胖组CC和CG基因型向GG基因型的血浆胰岛素差异显着，而BMI，腰臀比，空腹血糖和HOMA-IR差异无统计学意义。与AA + GG相比，Arg16Gly和Gln27Glu AG + CG的组合降低了肥胖的风险;但是，它与胰岛素抵抗无关。

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