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首页> 外文期刊>African Journal of Biotechnology >Induction of mammary gland tumor in female Sprague-Dawley rats with LA7 cells
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Induction of mammary gland tumor in female Sprague-Dawley rats with LA7 cells

机译：LA7细胞诱导雌性Sprague-Dawley大鼠乳腺肿瘤

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The current methods for tumor induction in breast cancer research animal models are time-consuming, hazardous, expensive, sometimes irreproducible and inconvenient. We successfully developed a new, simple and cost-effective method in developing solid mammary gland tumor in female Sprague-Dawley rat using LA7 rat mammary tumor cells. Tumors developed in 7- 8 weeks old rats within 6 to 8 days of subcutaneous injection of LA7 cells into the mammary gland pad. Tumor size increased exponentially for four weeks. Histopathology examination confirmed that the induced tumors were adenocarcinomas. Evaluation of blood enzymes showed significantly higher (P < 0.005) serum alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in tumor-bearing than in normal rats. This LA7 cell-induced rat mammary gland tumor model may be useful for studies in breast cancer drug or nutraceutical research and development.
机译：当前在乳腺癌研究动物模型中诱导肿瘤的方法耗时，危险，昂贵，有时无法再现且不便。我们成功开发了一种使用LA7大鼠乳腺肿瘤细胞开发雌性Sprague-Dawley大鼠实性乳腺肿瘤的新方法，简单且经济高效。在将LA7细胞皮下注射到乳腺垫的6至8天内，在7至8周大的大鼠中出现了肿瘤。肿瘤大小连续四个星期呈指数增长。组织病理学检查证实，诱导的肿瘤是腺癌。血液酶的评估显示，荷瘤小鼠的血清碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）明显高于正常大鼠（P <0.005）。此LA7细胞诱导的大鼠乳腺肿瘤模型可用于乳腺癌药物或营养保健品研究与开发。

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