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首页> 外文期刊>African Journal of Biotechnology >Antitumor activity of baicalein on the mice bearing U14 cervical cancer
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Antitumor activity of baicalein on the mice bearing U14 cervical cancer

机译：黄ical素对U14宫颈癌小鼠的抗肿瘤活性

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摘要

Baicalein is one of the major constituents of?Scutellaria baicalensis, and some cancer cells could be inhibited by it according to some studies in recent years. Mice tumor models of U14 cervical cancer was established in our study, baicalein of high and low dose (40 and 20 mg/kg, respectively) were given orally to mice. The tumor inhibition rates and the thymus (spleen) weight index were studied, the cell morphologies of tumor, liver and kidney were examined after HE stained, the percentage of apoptotic cells was detected by flow cytometer and the positive expression rates of Bcl-2 and Bax protein in tumor tissues were examined by the standard immunehistochemical SP method. The results showed that baicalein could inhibit the tumor growth obviously with the tumor inhibition rate of 58.98%. Besides, the apoptosis of tumor could be induced by baicalein with the apoptotic percentage of 16.92 ± 0.65%. Moreover, compared with the negative control group, the expression of Bcl-2 was reduced, while that of Bax was increased after the treatment of Baicalein. So, baicalein could inhibit the growth of U14 cervical cancer cells, and it might induce apoptosis by downregulating the level of Bcl-2 protein and upregulating that of Bax.
机译：黄ical素是黄S的主要成分之一，根据最近的一些研究，黄ical素可以抑制某些癌细胞。在我们的研究中建立了U14宫颈癌的小鼠肿瘤模型，将高剂量和低剂量的黄ical素（分别为40和20 mg / kg）口服给小鼠。观察肿瘤抑制率和胸腺（脾）重量指数，HE染色后观察肿瘤，肝，肾细胞形态，流式细胞仪检测凋亡细胞百分率，Bcl-2和Bcl-2阳性表达率通过标准的免疫组织化学SP方法检查肿瘤组织中的Bax蛋白。结果表明，黄ical苷具有明显的抑瘤作用，抑瘤率为58.98％。此外，黄ical苷可诱导肿瘤细胞凋亡，其凋亡百分率为16.92±0.65％。此外，与黄control素处理后的阴性对照组相比，Bcl-2的表达降低，而Bax的表达升高。因此，黄ical素可以抑制U14子宫颈癌细胞的生长，并可能通过下调Bcl-2蛋白水平和上调Bax诱导凋亡。

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