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首页> 外文期刊>African Journal of Biotechnology >Comparative antioxidant and hypoglycaemic effects of aqueous, ethanol and n-hexane extracts of leaf of Vitex doniana on streptozotocin-induced diabetes in albino rats
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Comparative antioxidant and hypoglycaemic effects of aqueous, ethanol and n-hexane extracts of leaf of Vitex doniana on streptozotocin-induced diabetes in albino rats

机译：荆条叶片水，乙醇和正己烷提取物对链脲佐菌素诱发的糖尿病白化病大鼠的抗氧化和降血糖作用的比较

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摘要

Several herbal preparations are used to treat diabetes, but their reported hypoglycemic effects are complex. This study therefore was designed to evaluate the effect of aqueous extract of?Vitex doniana?leaves on oxidative stress and lipid peroxidation in streptozotocin-induced diabetic and non-diabetic rats. Diabetes was induced intraperitoneally using 50 mg/kg streptozotocin, while diabetic rats were treated in 12 h cycles for four weeks with 100 mg/kg of the extract and glibenclamide (2.5 mg/kg). Nondiabetic control rats received distilled water. The levels of fasting blood sugar (FBS), thiobarbituric acid reactive substance (TBARS), aspartatate aminotransfrease (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), catalase (CAT) and superoxide dismutase (SOD) activities total, conjugated and unconjugated bilirubin concentration were assayed. The results indicate that the concentrations of TBARS, ALT, AST, ALP and bilirubin were significantly increased while the activities of SOD and CAT were reduced in the diabetic animals (p<0.05). The extract significantly increased CAT and SOD activity and reduced FBS, TBARS, ALT, AST, ALP and bilirubin concentrations significantly (p<0.05) compared to normal. However, glibenclamide treatment showed slight modification in the changes observed compared to the extract. The study concluded that the extract reversed diabetes and diabetes-induced oxidative changes in the hepatocytes, thus suggesting its use for the management of diabetic complications.
机译：几种草药制剂可用于治疗糖尿病，但据报道其降血糖作用复杂。因此，本研究旨在评估链Vi毒素诱导的糖尿病和非糖尿病大鼠中“ don豆”叶水提物对氧化应激和脂质过氧化的影响。使用50 mg / kg链脲佐菌素腹膜内诱导糖尿病，而糖尿病大鼠则在12 h周期内用100 mg / kg提取物和格列本脲（2.5 mg / kg）治疗四个星期。非糖尿病对照大鼠接受蒸馏水。空腹血糖（FBS），硫代巴比妥酸反应性物质（TBARS），天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT），碱性磷酸酶（ALP），过氧化氢酶（CAT）和超氧化物歧化酶（SOD）的总水平测定未结合的胆红素浓度。结果表明，糖尿病动物的TBARS，ALT，AST，ALP和胆红素浓度显着升高，而SOD和CAT活性降低（p <0.05）。与正常相比，该提取物显着提高了CAT和SOD活性，并显着降低了FBS，TBARS，ALT，AST，ALP和胆红素浓度（p <0.05）。然而，与提取物相比，格列本脲处理显示出所观察到的变化略有改变。研究得出结论，该提取物可逆转糖尿病和糖尿病引起的肝细胞氧化变化，因此建议将其用于糖尿病并发症的治疗。

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