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首页> 外文期刊>African Journal of Biotechnology >Evaluation of hypoglycaemic activity of ethanol extract of Gongronema latifolium (Asclepiadaceae) leaves
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Evaluation of hypoglycaemic activity of ethanol extract of Gongronema latifolium (Asclepiadaceae) leaves

机译：弓形虫叶片乙醇提取物的降血糖活性评估

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The mechanism of anti-diabetic activity of Gongronema latifolium was evaluated. The ethanol extract of the leaves of G. latifolium were fractionated using solvents of increasing polarity, namely n-hexane, chloroform, ethylacetate and ethanol. Phytochemical screening of the dried fractions were carried and then acute toxicity tests on mice carried out. The induction of diabetes mellitus was achieved with 150 mg/kg b.w for mild diabetes and 300 mg/kg b.w for the severe condition. The effects of the crude ethanol extract (CEE) and its fractions on alloxan-induced hyperglycaemia were monitored. The result obtained reveals that crude ethanol extract significantly and dose-dependently reduced hyperglycaemia. The fractions of the ethanol extract equally reduced hyperglycaemia but the level of reduction was affected by the phytochemical content. This suggests that an intact pancreas is required for the hypoglycaemic action which is the mechanism of action of the sulphonylureas.
机译：评价了弓形虫抗糖尿病活性的机制。用增加极性的溶剂，即正己烷，氯仿，乙酸乙酯和乙醇，分离出葛根叶片的乙醇提取物。进行干燥级分的植物化学筛选，然后对小鼠进行急性毒性试验。轻度糖尿病诱导为150 mg / kg b.w，重症诱导为300 mg / kgb.w。监测了粗乙醇提取物（CEE）及其馏分对四氧嘧啶诱导的高血糖症的影响。获得的结果表明，粗乙醇提取物显着且剂量依赖性地降低了高血糖症。乙醇提取物的馏分同样降低了高血糖症，但降低程度受植物化学成分的影响。这表明降血糖作用需要完整的胰腺，这是磺酰脲的作用机理。

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