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首页> 外文期刊>African Journal of Biotechnology >Anti-ulcer and gastric anti-secretory activities of seed extract of Buchholzia coriacea in Wistar Albino rats
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Anti-ulcer and gastric anti-secretory activities of seed extract of Buchholzia coriacea in Wistar Albino rats

机译：Wistar白化病大鼠Buchholzia coriacea种子提取物的抗溃疡和胃抗分泌活性

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Ethanol extract of Buchholzia coriacea seed was evaluated for anti-ulcer as well as anti-secretory activity in rats because of its use in Nigerian folk medicine as an anti-ulcer agent. Standard pharmacological methods were used to carry out phytochemical analysis of the plant. Quantitative phytochemical analysis of the ethanol extract of B. coriacea revealed the presence of alkaloids (101.88 ± 0.11 mg/100 g), flavonoids (46.88 ± 2.21 mg/100 g), tannins (0.16 ± 0.02 mg/100 g), oxalate (0.15 ± 0.01 mg/100 g) and terpenes (23.0 ± 0.30 μg/100 g). The extract at 200 and 400 mg/kg body weight, significantly (P<0.05) and dose-dependently suppressed the ulcerogenic effect induced by indomethacin in rat gastric mucosa relative to the controls. Similarly, the extract significantly (P<0.05) decreased histamine-mediated gastric acid secretion and also blocked histamine-induced contractile responses in isolated guinea-pig ileum in a similar fashion as the standard anti-histamine drug, chlorpheniramine. The extract had comparable ulcer protective potency with cimetidine, which is a standard drug used in the management of ulcer. The mechanism of the extract’s efficacy to protect the animals against indomethacin-induced ulcer may be diverse in nature (due to the presence of a number of bioactive constituents) but suppression of mediator effect of histamine is likely to play a predominant role in the observed activity.
机译：由于其在尼日利亚民间医学中作为抗溃疡剂的用途，因此评估了蒲uch种子乙醇提取物的抗溃疡和抗分泌活性。使用标准药理方法对植物进行植物化学分析。桔梗乙醇提取物的定量植物化学分析显示存在生物碱（101.88±0.11 mg / 100 g），类黄酮（46.88±2.21 mg / 100 g），单宁酸（0.16±0.02 mg / 100 g），草酸盐（ 0.15±0.01 mg / 100 g）和萜烯（23.0±0.30μg/ 100 g）。相对于对照组，以200和400 mg / kg体重的提取物显着（P <0.05）且剂量依赖性地抑制了吲哚美辛在大鼠胃粘膜中诱导的促溃疡作用。同样，提取物显着（P <0.05）减少了组胺介导的胃酸分泌，并以与标准抗组胺药扑尔敏类似的方式阻断了组胺诱导的豚鼠回肠中组胺诱导的收缩反应。提取物具有与西咪替丁相当的溃疡保护功效，西咪替丁是用于治疗溃疡的标准药物。提取物保护动物免受吲哚美辛诱导的溃疡的作用机理本质上可能是多种多样的（由于存在许多生物活性成分），但是抑制组胺的介导作用可能在观察到的活性中起主要作用。

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