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首页> 外文期刊>African Journal of Biotechnology >Hepatoprotective effects of Allium cepa (onion) extracts against paracetamol-induced liver damage in rats
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Hepatoprotective effects of Allium cepa (onion) extracts against paracetamol-induced liver damage in rats

机译：洋葱皮提取物对扑热息痛引起的大鼠肝损伤的保护作用

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Liver damage due to paracetamol hepatotoxicity is a major health challenge worldwide. It is against this background that this study was designed to determine the hepatoprotective effects of the increasing dosage of Allium cepa methanolic extracts on paracetamol induced hepatotoxic rats. Fifty-four (54) adult male albino rats comprising of nine normal and 45 paracetamol hepatotoxic rats were used for this study. The experimental design was the three by three Latin square design. Paracetamol hepatotoxicity was induced by single administration of paracetamol at 750 mg/kg ip on the first day of the experiment. The different biochemical parameters assessed were determined before the start of the study and subsequently monthly for the duration of the study. Blood samples were collected from the rat through the eye monthly for analysis and serum was obtained by centrifugation (5000 rpm for 10 min) and stored at -20°C prior to analysis. The effects of duration and increasing dosages (200, 300 and 450 mg/kg) of A. cepa methanolic extracts produced a duration dependent significant (p < 0.05) reductions in the alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total serum bilirubin (TSB) of paracetamol hepatotoxic rats after the duration of study when compared with those of the paracetamol, normal and silymarin control rats. A. cepa reduced alanine aminotransferase and total serum bilirubin in a dose dependent fashion whereas it reduced aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase level in a dose independent manner. A. cepa extracts studied showed potent hepatoprotective properties. It was evident that A. cepa extracts was able to reduce significantly all the elevated biochemical parameters due to paracetamol hepatotoxicity and this was collaborated by results of histopathological studies.
机译：对乙酰氨基酚肝毒性对肝脏的损害是全球范围内的一项重大健康挑战。在此背景下，本研究旨在确定剂量增加的葱属甲醇提取物对对乙酰氨基酚诱导的肝毒性大鼠的肝保护作用。本研究使用了54只（54）成年雄性白化病大鼠，其中包括9只正常和45只对乙酰氨基酚肝毒性大鼠。实验设计是三乘三拉丁方形设计。在实验的第一天，以750 mg / kg ip的对乙酰氨基酚单次给药诱发对乙酰氨基酚的肝毒性。在研究开始之前确定评估的不同生化参数，然后在研究期间每月确定一次。每月通过眼睛从大鼠中采集血样进行分析，并通过离心（5000 rpm，10分钟）获得血清，并在分析前保存在-20°C下。持续时间和剂量增加（200、300和450 mg / kg）的洋葱曲霉甲醇提取物的作用使谷丙转氨酶（ALT），天冬氨酸转氨酶（AST），碱性磷酸酶的持续时间显着减少（p <0.05）与对乙酰氨基酚，正常和水飞蓟素对照组大鼠相比，研究持续时间后对乙酰氨基酚肝毒性大鼠的（ALP），乳酸脱氢酶（LDH）和总血清胆红素（TSB）升高。洋葱曲霉以剂量依赖性方式降低丙氨酸氨基转移酶和总血清胆红素，而剂量依赖性地降低天冬氨酸氨基转移酶，碱性磷酸酶和乳酸脱氢酶水平。研究的洋葱曲霉提取物显示出有效的肝保护特性。显然，由于对乙酰氨基酚的肝毒性，洋葱头孢菌提取物能够显着降低所有升高的生化参数，这与组织病理学研究的结果相吻合。

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