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首页> 外文期刊>African Journal of Biotechnology >Acute and sub-chronic pre-clinical toxicological study of Averrhoa carambola L. (Oxalidaceae)
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Acute and sub-chronic pre-clinical toxicological study of Averrhoa carambola L. (Oxalidaceae)

机译：杨桃的急性和亚慢性临床前毒理学研究

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摘要

Averrhoa carambola?L., a species belonging to the Oxalidaceae family, is associated with neurological symptoms in individuals with renal diseases. The objective of this work was to accomplish a pre-clinical toxicological study of the hydroalcoholic extract (HE) from?A. carambola?leaves. Wistar rats and Swiss mice, both male and female, were used in these experiments. The rats were used in the acute toxicity assessment, with the extract administered at doses of 0.1 to 8.0 g/kg (oral route), and 0.5 to 3.0 g/kg (via intraperitoneal route). The mice received the extract in doses of 0.5 to 5.0 g/kg (via oral and intraperitoneal routes) and were observed for 14 days. Rats were also used in the sub-chronic toxicity evaluation, and divided into three groups (n=10): control group, HE 0.125 g/kg and HE 0.25 g/kg. These animals received HE for a 60 day period, at the end of which a macroscopic analysis of selected organs was performed with biochemical analysis of the blood. The acute toxicity assessment revealed that the HE of?A. carambola?L. presented low toxicity in the mice and rats. Furthermore, no signs of toxicity were present in the sub-chronic assessment.
机译：杨桃（Averrhoa carambola？L。）是草al科的一种，与肾病患者的神经系统症状有关。这项工作的目的是完成对？A中水醇提取物（HE）的临床前毒理学研究。杨桃叶。在这些实验中使用了雄性和雌性的Wistar大鼠和瑞士小鼠。将大鼠用于急性毒性评估，将提取物以0.1至8.0 g / kg（经口途径）和0.5至3.0 g / kg（经腹膜内途径）的剂量给药。小鼠以0.5至5.0g / kg的剂量（通过口服和腹膜内途径）接受提取物，并观察14天。大鼠也用于亚慢性毒性评估，分为三组（n = 10）：对照组，HE 0.125 g / kg和HE 0.25 g / kg。这些动物接受了60天的HE，最后用血液的生化分析对选定器官进行了宏观分析。急性毒性评估显示其HE为A。杨桃在小鼠和大鼠中表现出低毒性。此外，在亚慢性评估中没有毒性迹象。

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