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首页> 外文期刊>African Journal of Biotechnology >Protective role of aqueous extract of Hibiscus sabdariffa (calyx) against potassium bromate induced tissue damage in wistar rats
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Protective role of aqueous extract of Hibiscus sabdariffa (calyx) against potassium bromate induced tissue damage in wistar rats

机译：芙蓉花萼水提取物对溴酸钾诱导的wistar大鼠组织损伤的保护作用

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摘要

The protective role of aqueous extract of?Hibiscus sabdariffa?(calyx) against potassium bromate induced tissue damage was investigated in rat tissues (brain,kidney, stomach, spleen, heart and liver). The rats were divided into four groups. Group A was administered with 0.25 M sucrose only (base line control), Group B with 60 mg/kg body weight of potassium bromate, and Group C with 250 mg/kg body weight of extracts. Group D was administered 500 mg/kg body weight of extract. Group A and B were used as control groups, while Group C and D were the experimentals. The oral administration of potassium bromate to groups B, C and D were done eight hours before sacrifice. Lipid peroxidation was monitored by colorimetric determination of amino acid, protein and malondialdehyde level in the tissues. The organ-to-body weight ratio was taken as indication for inflammation and necrosis of the tissues investigated. The results of the test groups were statistically (p < 0.05) compared with the base line control and the group B. There was no significant difference in the organ-to-body weight ratio in all the tissues investigated at both doses, when compared with base line control, but showed a significant decrease when compared with group B. The protein level of the tissues investigated showed a similar trend but the stomach shows significant increase in the protein level. This may be due to accumulation of the toxicant inducing protein synthesis. Amino acid level decreased significantly?when compared with the base-line control and group B. This may be due to the extract ability to reduce proteolysis. Malondialdehyde level in the test groups decreased significantly in a dose dependent manner in all tissues investigated.
机译：在大鼠组织（脑，肾，胃，脾，心脏和肝脏）中研究了“芙蓉”花萼水提取物对溴酸钾诱导的组织损伤的保护作用。将大鼠分为四组。 A组仅施用0.25M蔗糖（基线对照），B组施用60mg / kg体重的溴酸钾，C组施用250mg / kg体重的提取物。 D组给予500mg / kg体重的提取物。 A组和B组用作对照组，而C组和D组为实验组。在处死前8小时，向B，C和D组口服溴酸钾。通过比色法测定组织中氨基酸，蛋白质和丙二醛的水平来监测脂质过氧化。器官与体重的比例被认为是所研究组织的炎症和坏死的指标。与基线对照组和B组相比，测试组的结果具有统计学意义（p <0.05）。与两组相比，在两种剂量下研究的所有组织的器官-体重比均无显着差异。基线对照，但与B组相比显示显着降低。研究组织的蛋白质水平显示出相似的趋势，但胃部蛋白质水平显着增加。这可能是由于毒物诱导蛋白质合成的积累。与基线对照组和B组相比，氨基酸水平显着下降。这可能是由于提取物减少了蛋白水解作用。测试组中丙二醛水平在所有研究的组织中均以剂量依赖性方式显着降低。

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