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首页> 外文期刊>African Journal of Biotechnology >In vitro antimicrobial potential of organic solvent extracts of novel actinomycetes isolated from forest soil
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In vitro antimicrobial potential of organic solvent extracts of novel actinomycetes isolated from forest soil

机译：从森林土壤中分离出的新型放线菌有机溶剂提取物的体外抗菌潜力

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In vitro screening of antibacterial and antifungal activities of hexane, chloroform, ethyl acetate, methanol and water extracts of selected promising actinomycetes strains were studied towards Gram-positive, Gram-negative bacteria, dermatophytes and opportunistic pathogens. Crude antimicrobial metabolites were extracted by liquid-liquid extraction and solid-liquid extraction method using hexane, chloroform, ethyl acetate and methanol. The lowest minimum inhibitory concentration (MIC) of the extracts was assessed by the broth micro dilution method. All the extracts obtained from eight strains showed promising activity against tested Gram-positive bacteria. The hexane extracts of strain ERI-1 exhibited activity against Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis at a concentration of 5 mg/ml. Ethyl acetate extract of strain ERI-4 showed MIC of 5 mg/ml but S. epidermidis and S. aureus. B. subtilis exhibited activity at 2.5 mg/ml. However, ethyl acetate and lyophilized water extract of strain ERI-3 inhibited the growth of Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum and Scropulariopsis sp at 10 mg/ml. Overall significant antibacterial and antifungal activities were noted in the ethyl acetate extract of ERI-1 and ERI-3. Methanol extract of ERI-26 exhibited good antibacterial and antifungal activities.
机译：体外筛选了一些有希望的放线菌菌株的己烷，氯仿，乙酸乙酯，甲醇和水提取物的抗菌和抗真菌活性，以研究革兰氏阳性，革兰氏阴性细菌，皮肤真菌和机会病原体。通过使用己烷，氯仿，乙酸乙酯和甲醇的液-液萃取和固-液萃取方法萃取粗制的微生物代谢物。提取物的最低最低抑菌浓度（MIC）通过肉汤微量稀释法进行评估。从八种菌株获得的所有提取物均显示出对测试的革兰氏阳性细菌有希望的活性。菌株ERI-1的己烷提取物对枯草芽孢杆菌，金黄色葡萄球菌和表皮葡萄球菌的活性为5mg / ml。菌株ERI-4的乙酸乙酯提取物的MIC为5mg / ml，但表皮葡萄球菌和金黄色葡萄球菌为。枯草芽孢杆菌显示出2.5 mg / ml的活性。但是，乙酸乙酯和ERI-3菌株的冻干水提取物以10 mg / ml抑制了毛癣菌，红毛癣菌，絮状表皮菌和鞘脂菌的生长。在ERI-1和ERI-3的乙酸乙酯提取物中发现了总体上显着的抗菌和抗真菌活性。 ERI-26的甲醇提取物具有良好的抗菌和抗真菌活性。

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