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首页> 外文期刊>African Journal of Biotechnology >Comparative acute toxicity and oxidative stress responses in tadpoles of Amietophrynus regularis exposed to refined petroleum products, unused and spent engine oils
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Comparative acute toxicity and oxidative stress responses in tadpoles of Amietophrynus regularis exposed to refined petroleum products, unused and spent engine oils

机译：暴露于精制石油产品，未使用和已用过的机油的regular螨中t的比较急性毒性和氧化应激反应

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The relative acute toxicity of refined petroleum (diesel, kerosene and petrol), unused and spent engine oils as well as their abilities to alter the activities of superoxide dismutase (SOD) and cause lipid peroxidation in tadpoles of the common African toad, Amietophrynus regularis were evaluated. ?After 48 h of exposures, kerosene was found to be the most toxic (LC50= 4930 mg/L) while the least toxic was unused engine oil (LC50 = 7777 mg/L). However, by 96 h of exposure, spent engine oil was found to be the most toxic (LC50 = 2915 mg/L) while unused engine oil remained the least toxic (LC50= 7353 mg/L). Further, assessment of oxidative stress markers was conducted using sub lethal concentrations of the test compounds (1/100th 96 h LC50). There was significant inhibition of SOD in exposed tadpoles compared to the control (P<0.05) with the least activity recorded in tadpoles exposed to petrol, while unused engine oil recorded the highest. The results of the lipid peroxidation assay, determined by measuring the levels of malondialdehyde (MDA) indicated significantly higher levels in the exposed individuals compared to the control. Unused engine oil caused the highest level of MDA production while diesel induced the least level. Tadpoles exposed to diesel, kerosene, petrol and spent engine oil exhibited consistent responses among the three test parameters, however inconsistent responses were observed in tadpoles exposed to unused engine oils. The relevance of the comparisons in biomarker selection and ecotoxicology were discussed.
机译：精制石油（柴油，煤油和汽油），未使用和用过的机油的相对急性毒性以及它们改变超氧化物歧化酶（SOD）的活性并引起普通非洲蟾蜍regular中脂质过氧化的能力。评估。 ？暴露48小时后，发现煤油毒性最高（LC50 = 4930 mg / L），而毒性最低的是未使用的机油（LC50 = 7777 mg / L）。但是，在暴露96小时后，发现用过的机油毒性最高（LC50 = 2915 mg / L），而未使用的机油毒性最低（LC50 = 7353 mg / L）。此外，使用亚致死浓度的测试化合物进行氧化应激标记的评估（1 / 100，96小时LC50）。与对照组相比，暴露t中的SOD抑制显着（P <0.05），而t暴露于汽油中的活性最低，而未使用的机油则最高。通过测量丙二醛（MDA）的水平确定的脂质过氧化测定的结果表明，与对照组相比，暴露个体的水平明显更高。未使用的机油导致MDA产量最高，而柴油则最低。暴露于柴油，煤油，汽油和废机油的在三个测试参数中表现出一致的响应，但是，暴露于未使用的机油的engine却观察到不一致的响应。讨论了在生物标志物选择和生态毒理学方面比较的相关性。

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