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首页> 外文期刊>African Journal of Biotechnology >Effect of resin from Commiphora swynnertonii on white blood cell and selected haematopoietic organs in albino mice (Mus musculus)
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Effect of resin from Commiphora swynnertonii on white blood cell and selected haematopoietic organs in albino mice (Mus musculus)

机译：斯氏Commonphora swynnertonii树脂对白化病小鼠（Mus musculus）白细胞和某些造血器官的影响

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Commiphora swynnertonii is among the most commonly used medicinal plants by pastoralist communities especially in northern regions of Tanzania. The effect of resin from this plant on white blood cells (WBC) and haematopoietic organs was studied using albino mice. Sixty adult mice were randomly assigned into four groups (n = 15). G1 acted as control whereas G2, G3 and G4 received oral doses of 50, 100 and 200 mg resin per kg body weight, respectively for 35 days consecutively. Blood samples for differential and total WBC count were collected before treatment and on days 7, 14, 28 and 35 after treatment. Also, three mice from each group were humanely sacrificed before treatment, on day 14 and 35 after treatment. Sternum, liver and spleen samples from sacrificed mice were collected for assessment of any effects of the resin on haematopoietic organs. Results showed that mice in G2 and G4 had a significant increase (P < 0.05) in total WBC counts by day 7 as compared to the control group. This trend was then followed by a gradual decrease towards end of the experiment. No significant changes in total WBC counts were observed in G3 following treatment. The effect of C. swynnertonii resin on differential WBC count was non-specific and insignificant; G1 and G2 mice had their lymphocyte and monocyte counts slightly increasing with time while that of G3 and G4 decreased slightly or remained unchanged. Neutrophils counts decreased significantly in G1 and G2, but there were no significant changes for G3 and G4. Changes in the haematopoietic tissues following exposure to the resin included increased cellularity of sternal bone marrow as compared to spaces occupied by adipocytes. In particular, there were different developmental stages of granulocytes, erythroblasts and all megakaryocytic series. Small patches of erythropoietic series and lymphoblastic cells were observed in the liver and spleen respectively of the mice that received resin. It is concluded that oral administration of C. swynnertonii resin to mice caused a significant but transient increase in total white cell counts as a short-term effect. Prolonged exposure to the resin was associated with changes in the haematopoietic system such as increased cellularity of bone marrow and erythropoietic patches in liver and spleen.
机译：Swynnertonii属Commiphora swynnertonii是牧民社区特别是坦桑尼亚北部地区最常用的药用植物之一。使用白化病小鼠研究了该植物树脂对白细胞（WBC）和造血器官的影响。 60只成年小鼠被随机分为四组（n = 15）。 G1作为对照，而G2，G3和G4分别连续35天接受每公斤体重50、100和200 mg树脂的口服剂量。在治疗前以及治疗后第7、14、28和35天收集血样，以进行差异性和总WBC计数。另外，在治疗前，治疗后第14和35天，将每组三只小鼠人道处死。收集处死小鼠的胸骨，肝脏和脾脏样品，以评估树脂对造血器官的任何作用。结果显示，与对照组相比，到第7天，G2和G4小鼠的WBC总计数显着增加（P <0.05）。然后，随着这种趋势的发展，实验结束时逐渐减少。治疗后在G3中未观察到WBC总计数的显着变化。 Swynnertonii树脂对白细胞计数差异的影响是非特异性的且微不足道。 G1和G2小鼠的淋巴细胞和单核细胞计数随时间而略有增加，而G3和G4的小鼠则略有减少或保持不变。 G1和G2中的中性粒细胞计数显着下降，但G3和G4没有明显变化。与脂肪细胞占据​​的空间相比，暴露于树脂后的造血组织变化包括胸骨骨髓细胞增多。特别是，粒细胞，成红细胞和所有巨核细胞系列都有不同的发育阶段。分别在接受树脂的小鼠的肝脏和脾脏中观察到小数目的促红细胞生成系列和淋巴母细胞。结论是，口服C.swinernertonii树脂对小鼠造成短期总白细胞计数显着但短暂的增加。长时间接触该树脂与造血系统的变化有关，例如骨髓细胞增多以及肝和脾中的造血斑。

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