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首页> 外文期刊>African Journal of Biotechnology >Uterotonic effect of aqueous extract of Launaea taraxacifolia Willd on rat isolated uterine horns
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Uterotonic effect of aqueous extract of Launaea taraxacifolia Willd on rat isolated uterine horns

机译：太子参水提取物对大鼠离体子宫角的子宫收缩作用

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Launaea taraxacifolia is used by the traditional health practitioners in Sokoto to ease labour pains and augment labour thereby facilitating child birth. This study examined the effect of the aqueous extract of the whole plant on isolated uterus from non-pregnant rats pre-treated with stilbestrol and from pregnant rats in late gestation. This was compared to the effects of uterine contraction agonists, namely; oxytocin, histamine and acetylcholine. The possible mechanism of uterotonic activity was investigated using antagonists such as piroxicam, mepyramine and atropine. The aqueous extract of L. taraxacifolia produced a dose-dependent uterotonic activity. In the stilbestrol treated non-pregnant uterus, the force generated at 400, 800 and 1600 mg/ml was 1.469, 1.624 and 1.793 times greater than the control, respectively. In the pregnant rat uterus, a dose of 400, 800 and 1600 mg/ml generated a force of contraction that was 1.36, 1.51 and 1.66 times greater than the control, respectively. When the relative potency was compared to oxytocin, the gold standard uterotonin, L. taraxacifolia at 1600 mg/ml was found to be 0.08 times more potent than 0.4 μg/ml oxytocin in the stilbestrol treated non-pregnant rat uterus. In the pregnant rat uterine strip however, oxytocin was 0.17 times more potent than 1600 mg/ml L. taraxacifolia. Pre-treating the tissue with either atropine or mepyramine before administering the extract showed an inhibitory effect while piroxicam completely abolished its uterotonic effect, showing a probable moderate stimulation of muscarinic and histamine receptors but majorly the oxytocin receptors by L. taraxacifolia. A preliminary phytochemical screening of the extract shows the presence of saponins, tannins, flavonoids and steroids. A dose of 2000 mg/kg/oral of L. taraxacifolia was found to be well tolerated in rats with no sign of toxicity. Thus, L. taraxacifolia contains phytochemicals with uterotonic properties thereby justifying its ethnobotanical use in easing labour.
机译：索科托的传统卫生从业人员使用太子参（Launaea taraxacifolia）减轻劳苦并增加劳力，从而促进孩子的分娩。这项研究检查了整个植物的水提取物对未接受雌甾醇预处理的非妊娠大鼠和妊娠后期妊娠大鼠离体子宫的影响。将其与子宫收缩激动剂的作用进行比较，即：催产素，组胺和乙酰胆碱。使用诸如吡罗昔康，美吡拉明和阿托品等拮抗剂研究了子宫内膜活性的可能机制。蒲公英乳杆菌的水提取物产生剂量依赖性的子宫收缩活性。在经stilbestrol处理的非妊娠子宫中，以400、800和1600 mg / ml产生的力分别是对照组的1.469、1.624和1.793倍。在怀孕的大鼠子宫中，400、800和1600 mg / ml的剂量产生的收缩力分别是对照组的1.36、1.51和1.66倍。当将相对效力与催产素进行比较时，发现金标准的子宫降钙素，蒲公英乳杆菌（L. taraxacifolia）在stilbestrol治疗的非妊娠大鼠子宫中的催产素效力比催产素0.4μg/ ml高0.08倍。然而，在怀孕的大鼠子宫剥皮术中，催产素的效力是1600 mg / ml蒲公英乳杆菌的0.17倍。在给予提取物之前用阿托品或美吡拉明对组织进行预处理显示出抑制作用，而吡罗昔康完全废除了其子宫收缩作用，显示出可能对中毒毒蕈碱和组胺受体产生中等程度的刺激，但主要是由蒲公英乳杆菌对催产素受体产生了刺激作用。提取物的初步植物化学筛选显示存在皂苷，单宁，类黄酮和类固醇。发现在大鼠中对蒲公英乳杆菌2000 mg / kg /口服的剂量具有良好的耐受性，没有毒性迹象。因此，蒲公英（L. taraxacifolia）含有具有子宫收缩性的植物化学物质，从而证明了其民族植物学用途可减轻劳动强度。

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