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首页> 外文期刊>African Journal of Biotechnology >Comparative evaluation of the antimicrobial activity of Citrullus colocynthis immature fruit and seed organic extracts
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Comparative evaluation of the antimicrobial activity of Citrullus colocynthis immature fruit and seed organic extracts

机译：瓜果未成熟果实和种子有机提取物抗菌活性的比较评价

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Gastrointestinal problems, dermatological, gynaecological and pulmonary infections produced by micro-organisms are widespread in the entire globe. The treatment of these infections is mainly based on the use of synthetic drugs which have lost, in recent years, their effectiveness, due to the development of resistant strains and the rise of opportunistic fungal infections. Tunisian traditional medicine is a potential source of new remedies namely,?Citrullus colocynthis?Schrad. (Cucurbitaceae). Lyophilized aqueous and organic extracts from immature fruits and seeds were screened for activity against gram-negative (Escherichia coli,?Pseudomonas aeruginosa,?Salmonella typhimurium,?Vibrio?parahaemolyticus and Vibrio alginolyticus)?and gram-positive (Enterococcus faecalis,?Staphylococcus aureus,Staphylococcus epidermidis,?Listeria monocytogenes?and?Micrococcus luteus) bacteria and various?Candida?spp. (Candida glabrata,?Candida albicans,?Candida parapsilosis?and?Candida kreusei). Minimal inhibition concentrations (MICs) and minimal bactericidal/fungicidal concentrations (MBCs/MFCs) were used to investigate the antimicrobial activity. Extracts from the two?C. colocynthis?Schrad. organs, at immature state, inhibited the growth of all the tested strains. The highest antibacterial effects were obtained against?E. coli?(MIC?= 0.006?mg/ml) with the fruit methanol and the seed petroleum extracts. Regarding the anticandidal activity assessment, seed extracts showed the?lowest results. This study demonstrated the broad spectrum antimicrobial activity of?C. colocynthis?immature fruit and seed extracts.
机译：由微生物产生的胃肠道问题，皮肤病，妇科和肺部感染在全球范围内普遍存在。这些感染的治疗主要基于合成药物的使用，由于抗药性菌株的发展和机会性真菌感染的增加，近年来合成药物的有效性已丧失。突尼斯传统医学是潜在的新疗法来源，即“ Citrullus colocynthis” Schrad。 （葫芦科）。筛选未成熟果实和种子的冻干水和有机提取物对革兰氏阴性菌（大肠杆菌，铜绿假单胞菌，鼠伤寒沙门氏菌，副溶血性弧菌和溶藻弧菌）和革兰氏阳性（粪肠球菌，葡萄球菌）的活性。 ，表皮葡萄球菌，单核细胞增多性李斯特菌和黄褐微球菌）和各种念珠菌。 （glabrata念珠菌，白色念珠菌，parapsilosis念珠菌和kreusei念珠菌）。最小抑菌浓度（MICs）和最小杀菌/杀真菌浓度（MBCs / MFCs）用于研究抗菌活性。从两者中提取？ colocynthis？Schrad。处于未成熟状态的器官会抑制所有测试菌株的生长。对？E的抗菌作用最高。用水果甲醇和种子石油提取物提取大肠杆菌（MIC ＝0.006μg/ ml）。关于抗候选活性评估，种子提取物显示出最低的结果。这项研究证明了？C的广谱抗菌活性。 colocynthis？未成熟的水果和种子提取物。

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