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首页> 外文期刊>African Journal of Biotechnology >Antibacterial effect of Jordanian propolis and isolated flavonoids against human pathogenic bacteria
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Antibacterial effect of Jordanian propolis and isolated flavonoids against human pathogenic bacteria

机译：约旦蜂胶和分离的类黄酮对人体病原菌的抗菌作用

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Propolis is a natural product widely consumed in folk medicine.?The present study was carried out to investigate the antibacterial activity of Jordanian propolis, collected from two locations with two different dominant floras (Type1; Pine trees and Type ll; Oak trees).?Zones of inhibition and minimum inhibitory concentrations (MICs) were determined on methicillin resistant?Staphylococcus aureus?(MRSA), multidrug resistant?Escherichia coli?and standard strains of both bacteria. Propolis Type I and Type II showed antibacterial activity against MRSA?(MIC?4.69 and 18.75 μg ml-1,?respectively). Crude propolis from Type I showed higher antibacterial activity than Type II against the tested bacteria. Three pure phenolic compounds (three flavonoids) namely, pinobanksin-3-O-acetate, pinocemberin and chrysin, were isolated?from fractions I-2 and I-4, and screened?in?vitro?for antibacterial activity. Pinobanksin-3-O-acetate and pinocembrin exhibited antibacterial activity especially against MRSA, while chrysin was only active against standard?S. aureus. This is the first report that shows?in vitro?antibacterial activity of?isolated?flavonoids from Jordanian propolis against standard and resistant strains of?E. coli?and MRSA.Overall, results of this study highlight the important role of?propolis botanical source on the antibacterial activity of such natural material which might affect its medical applications.
机译：蜂胶是在民间医学中广泛消费的天然产物。本研究旨在调查约旦蜂胶的抗菌活性，该产品是从两个具有两种不同优势菌群（Type1;松树和ll型;橡树）的地点采集的。在耐甲氧西林的“金黄色葡萄球菌”（MRSA），耐多药的“大肠杆菌”和这两种细菌的​​标准菌株中确定抑制区和最低抑菌浓度。 I型和II型蜂胶显示出对MRSAα的抗菌活性（分别为MIC≥4.69和18.75μgml-1）。 I型粗蜂胶对被测细菌显示出比II型更高的抗菌活性。从级分I-2和I-4中分离出三种纯酚类化合物（三种类黄酮），即Pinobanksin-3-O-乙酸盐，pinocemberin和chrysin，并在体外进行了抗菌活性筛选。 Pinobanksin-3-O-乙酸盐和松果蛋白对MRSA尤其具有抗菌活性，而Chrysin仅对标准S活性。金黄色的。这是第一份显示约旦蜂胶中分离的类黄酮对标准和抗性菌株E的体外抗菌活性的报告。总的来说，这项研究的结果突出了蜂胶植物来源对这种天然物质的抗菌活性的重要作用，这可能会影响其医学应用。

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