Evidence for a role of KISS-1/GPR54 system in decreased luteinizing hormone (LH) secretion in fasted prepubertal ewes

Jun Wang; Haizhu zhou; Tao Zhang; Lei Sun; Jing Xu; Yujie Lou

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Evidence for a role of KISS-1/GPR54 system in decreased luteinizing hormone (LH) secretion in fasted prepubertal ewes

机译：KISS-1 / GPR54系统在禁食青春前母羊的黄体生成激素（LH）分泌减少中的作用的证据

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Short fasting has been shown to?suppress luteinizing hormone (LH) secretion in ewes, however,?the molecular mechanism underlying this phenomenon is not clear. Based on recent discovery of the crucial role of KiSS-1/GPR54 system in the central control of the GnRH axis, we hypothesized that KiSS-1/GPR54 system?was?involvedin the inhibitory effect of fasting on LH secretion in ewes. To test this hypothesis, we fed six prepubertal ewes subjected to a control diet or fasting 72 h and determined the expression of KiSS-1/GPR54 system in hypothalamus. To further confirm the effects of fasting on the expression of KiSS-1/GPR54 system in hypothalamus asresponsible for the suppression of LH secretion in ewes, we also investigated the effect of kisspeptin-10 on the LH secretion in fasted and?standard feeding?prepubertal ewes. The results show that?fasting for 72 h could significantly suppress hypothalamic expression of KiSS-1 and GPR54 gene and LH secretion in prepubertal ewes.?In addition,?intravenous injection of 1 mg of kisspeptin-10 could significantly increase LH secretion in fasted and standard ewes. These data suggest that?the inhibitory effect of fasting on LH secretion of?prepubertal ewes?is probably via decreasing the expression of KiSS-1/GPR54 system in hypothalamus.

机译：空腹禁食可以抑制母羊的黄体生成激素（LH）分泌，但是，这种现象的分子机制尚不清楚。基于最近发现KiSS-1 / GPR54系统在GnRH轴的中央控制中的关键作用，我们假设KiSS-1 / GPR54系统参与了禁食对母羊LH分泌的抑制作用。为了验证这一假设，我们喂养了六只青春期前母羊，进行对照饮食或禁食72 h，并确定其下丘脑中KiSS-1 / GPR54系统的表达。为了进一步确认禁食对母羊下丘脑分泌LH分泌负相关的下丘脑KiSS-1 / GPR54系统表达的影响，我们还研究了空腹和“标准喂养”前青春期kisseptin-10对LH分泌的影响。母羊。结果表明：禁食72 h可以显着抑制青春期前母羊下丘脑KiS-1和GPR54基因的表达以及LH的分泌。此外，静脉注射1 mg kisspeptin-10可以显着增加禁食和饥饿时LH的分泌。标准母羊。这些数据表明，禁食对青春期前母羊LH分泌的抑制作用可能是通过降低下丘脑中KiSS-1 / GPR54系统的表达来实现的。

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《African Journal of Biotechnology》 |2012年第3期|共7页
作者
Jun Wang; Haizhu zhou; Tao Zhang; Lei Sun; Jing Xu; Yujie Lou;
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中图分类生物工程学（生物技术）;
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FastingKiSS-1/GPR54 systemhypothalamusLHewes;

机译：空腹KiSS-1 / GPR54系统下丘脑;

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1. Postmenopausal increase in KiSS-1, GPR54, and luteinizing hormone releasing hormone (LHRH-1) mRNA in the basal hypothalamus of female rhesus monkeys. [J] . Kim W, Jessen HM, Auger AP Peptides: An International Journal . 2009,第1期

机译：雌性恒河猴基底下丘脑中KiSS-1，GPR54和促黄体生成激素释放激素（LHRH-1）mRNA的绝经后增加。
2. Neuropeptide Y (NPY) delays the oestrogen-induced luteinizing hormone (LH) surge in the ovariectomized ewe: further evidence that NPY has a predominant negative effect on LH secretion in the ewe. [J] . Estrada KM, Pompolo S, Morris MJ, Journal of neuroendocrinology . 2003,第11期

机译：神经肽Y（NPY）延缓了卵巢切除母羊的雌激素诱导的促黄体生成激素（LH）激增：进一步的证据表明NPY对母羊LH分泌具有主要的负面影响。
3. IMPAIRMENT IN FOLLICLE-STIMULATING HORMONE SECRETION BY DIFFERENT TREATMENTS WITH FOLLICULAR FLUID AS A SOURCE OF INHIBIN BLOCKS THE ABILITY OF PULSATILE LUTEINIZING HORMONE TO INDUCE PREOVULATORY SURGES OF GONADOTROPINS IN PREPUBERTAL EWE LAMBS [J] . Tortonese DJ, Gomezbrunet A Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction . 1996,第2期

机译：以烟碱为源的不同液体处理对激素刺激激素分泌的阻滞作用，可能会引起脂蛋白化激素的产生，从而引起产前羊羔中促性腺激素的前期手术
4. Synthesis and structural studies of new analogues of the decapeptide Luteinizing Hormone-Releasing Hormone (LHRH) [C] . Aikaterini A.Zompra, Dimitris Vachliotis, Georgios A.Spyroulias, European Peptide Symposium . 2002

机译：疏皮肽丁骨释放激素（LHRH）新型类似物的合成与结构研究
5. Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ [D] . Nestor, Casey C. 2012

机译：母羊促性腺激素释放激素/促黄体激素分泌的三种介导类固醇负反馈的神经肽的作用的证据：亲肽，神经激肽B和孤儿蛋白FQ
6. Postmenopausal Increase in KiSS-1 GPR54 and Luteinizing Hormone Releasing Hormone (LHRH-1) mRNA in the Basal Hypothalamus of Female Rhesus Monkeys [O] . WooRam Kim, Heather M. Jessen, Anthony P. Auger, -1

机译：雌性恒河猴基础下丘脑中KiSS-1GPR54和促黄体生成激素释放激素（LHRH-1）mRNA的绝经后增加
7. Fasting-Induced Changes in Pulsatile Luteinizing Hormone (LH) Secretion in Male Rats. The Role of Testosterone and the Hypothalamic Paraventricular Nucleus. [O] . Hiroko TSUKAMURA, Sakiko YAMADA, Kei-ichiro MAEDA 2000

机译：持续抗脉状叶氏叶氏叶蝶阀（LH）分泌术中的禁区诱导的变化。睾酮和下丘脑腺腺内核的作用。
8. Intracellular Mechanism of the Action of Inhibin on the Secretion of Follicular Stimulating Hormone and of Luteinizing Hormone Induced by LH-RH in Vitro [R] . Lecomte-yerna, M. J., Hazee-hagelstein, M. T., Charlet-renard, C., 1982

机译：抑制素对LH-RH诱导的卵泡刺激素和促黄体激素分泌的细胞内作用机制

Evidence for a role of KISS-1/GPR54 system in decreased luteinizing hormone (LH) secretion in fasted prepubertal ewes

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