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首页> 外文期刊>African Journal of Biotechnology >Alteration in lipid metabolism induced by a diet rich in soya-oil and amylopectin in a rat model
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Alteration in lipid metabolism induced by a diet rich in soya-oil and amylopectin in a rat model

机译：高脂大豆油和支链淀粉饮食对大鼠模型脂质代谢的影响

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This present study was designed to evaluate the impact of different dietary regimens on lipid metabolism in brain, liver and plasma of albino rat model. Twenty (20) male Wister albino rats (110 g) were assigned to two dietary groups and housed individually. One group received a control diet enriched in 20% soy- oil and another enriched with 20% amylopectin. The starved group was fed primarily with carboxyl methyl cellulose (CMC).?Daily growth rate and average condition factor of each group was monitored for 14 days. Lipid profiles of brain, liver and plasma were analyzed by colorimetric, immunological, thin layer chromatography and?gas chromatography-mass spectrometry.?Elevated serum total cholesterol was indicated in rats of starved, oil fed and starch fed rats by factors of 0.40, 0.65 and 0.75 mmol/L respectively when compared with the control. Low density lipoprotein (LDL) cholesterol was 0.9, 1.1 and 0.95 mmol/L higher in starved, oil fed and starch fed rat groups, respectively when compared with the control group. Alteration in feeding pattern revealed a marked decrease in the levels of the steroidal sex hormones in the starved and other dietary groups compared to the control. Hepatic and liver lipid profile revealed the polar lipids tentatively identified altered expression of diphosphatidyl glycerol, phosphatidyl choline, phosphatidyl serine, and cholesterol in order of decreasing polarity. GC-MS results showed?a shift in the ratio of saturated to unsaturated fatty acids in the test groups. Lauric acid was observed to be predominantly present in the starved group.
机译：本研究旨在评估不同饮食方案对白化病大鼠模型的脑，肝和血浆脂质代谢的影响。将二十只（20）雄性Wister白化病大鼠（110 g）分为两个饮食组，并单独饲养。一组接受了富含20％豆油的对照饮食，另一组接受了20％支链淀粉的丰富饮食。饥饿的组主要喂食羧甲基纤维素（CMC）。监测每组的每日生长速度和平均条件因子，持续14天。用比色法，免疫学，薄层色谱法和“气相色谱-质谱法”分析了脑，肝和血浆的脂质谱。饥饿，油饲和淀粉喂养大鼠的血清总胆固醇升高，分别为0.40、0.65与对照相比分别为0.75mmol / L和0.75mmol / L。与对照组相比，饥饿，油喂养和淀粉喂养的大鼠组低密度脂蛋白（LDL）胆固醇分别高0.9、1.1和0.95 mmol / L。喂养方式的变化表明，与对照组相比，饥饿和其他饮食组的类固醇性激素水平显着下降。肝和肝脂质谱图显示，极性脂质初步确定了二磷脂酰甘油，磷脂酰胆碱，磷脂酰丝氨酸和胆固醇的表达按极性递减的顺序改变。 GC-MS结果表明，测试组中饱和脂肪酸与不饱和脂肪酸的比率发生了变化。观察到在饥饿组中主要存在月桂酸。

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