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首页> 外文期刊>African Journal of Biotechnology >Acute and subacute toxicity study of ethanolic extract of the stem bark of Faidherbia albida (DEL) A. chev (Mimosoidae) in rats
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Acute and subacute toxicity study of ethanolic extract of the stem bark of Faidherbia albida (DEL) A. chev (Mimosoidae) in rats

机译：费氏飞蛾（Aid a。chev，Mimosoidae）茎皮乙醇提取物对大鼠的急性和亚急性毒性研究

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Faidherbia albida?(Del.) A. Chev (mimosoidae) is widely used in African traditional medicine (ATM) for management of fever, diarrhoea and human trypanosomiasis.Acute and sub-acute toxicity profiles of ethanolic stem bark extract of?F. albida?were evaluated in wistar albino rats. The acute toxicity was studied using the method of Lorke (1983). In the sub-acute toxicity study, four groups of six rats per group were used. The control group (1) received 10 ml normal saline/kg body weight while groups 2, 3 and 4 received oral?daily doses of 125, 250 and 500 mg extract/kg body weight respectively for 21 days. The effects of the extract on clinical signs, feed and water intake, body weight changes, haematology, plasma biochemical parameters, relative organ weight (ROW) were evaluated. The oral LD50?of the extract was estimated to be greater than 5000 mg/ kg body weight. The extract produced slight increase in body weight of rats given 125 mg extract/kg body weight. However, dose-dependent highly significant (P < 0.01) decrease in body weight was observed at 250 and 500 mg/ kg-treated rats in weeks 2 and 3 of the study. Feed and water intake was not affected by the treatment. ROW for all organs was not affected by the treatment except significant (P < 0.05) increase in the testes of rats treated with 250 and 500 mg extract/kg body weight. Although the treatment elicited highly significant (P < 0.01) changes in the levels of the hepatic and some of the haematological parameters, they were within the normal reference range for rats. This study revealed that while the stem bark of the plant may be considered relatively safe when used sub-acutely, further investigation is needed to ascertain its effect on the male reproductive system as well as its effect on chronic administration.
机译：Faidherbia albida？（Del。）A. Chev（mimosoidae）被广泛用于非洲传统医学（ATM）中，用于控制发烧，腹泻和人类锥虫病。？F乙醇茎皮提取物的急性和亚急性毒性特征。在wistar白化病大鼠中评估了白化病。使用Lorke（1983）的方法研究了急性毒性。在亚急性毒性研究中，使用了四组，每组六只大鼠。对照组（1）接受10 ml生理盐水/ kg体重，而第2、3和4组分别口服口服125、250和500 mg提取物/ kg体重，持续21天。评估了提取物对临床体征，饲料和水摄入量，体重变化，血液学，血浆生化参数，相对器官重量（ROW）的影响。提取物的口服LD50估计大于5000 mg / kg体重。给定125 mg提取物/ kg体重，提取物会使大鼠的体重略有增加。然而，在研究的第2周和第3周，在250和500 mg / kg处理的大鼠中观察到了体重的剂量依赖性高度显着降低（P <0.01）。饲料和水的摄入量不受治疗的影响。除用250和500 mg提取物/ kg体重处理的大鼠的睾丸显着增加（P <0.05）外，所有器官的ROW均不受治疗的影响。尽管该治疗引起肝脏水平和某些血液学参数的显着变化（P <0.01），但它们在大鼠的正常参考范围内。这项研究表明，虽然亚急性使用该植物的茎皮可能被认为是相对安全的，但还需要进一步研究以确定其对雄性生殖系统的影响以及对慢性给药的影响。

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