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首页> 外文期刊>African Journal of Biotechnology >Interleukin-6 but not soluble adhesion molecules has short-term prognostic value on mortality in patients with acute ST-segment elevation myocardial infarction
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Interleukin-6 but not soluble adhesion molecules has short-term prognostic value on mortality in patients with acute ST-segment elevation myocardial infarction

机译：白细胞介素6但非可溶性黏附分子对急性ST段抬高型心肌梗死患者的死亡率具有短期预后价值

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Inflammatory responses represent an important element in all phases of the atherosclerotic process.?This recognition has stimulated the evaluation of different inflammatory markers as potential predictors of cardiovascular risk. This study was designed to simultaneously measure serum levels of interleukin-6 (IL-6),?soluble intercellular adhesion molecule-1?(sICAM-1), soluble vascular cell adhesion molecule-1?(sVCAM-1),?and?soluble?P-selectin (sP-selectin) in patients with acute ST-segment elevation myocardial infarction (STEMI) and to evaluate their ability to predict?short-term?prognosis.?We recruited 263 consecutive patients admitted toour institute within 6 h of symptoms onset?with the diagnosis of?first STEMI. Clinical data were recorded and serum admission levels of IL-6,?sICAM-1, sVCAM-1?and sP-selectin were measured. The patients were then followed prospectively for the occurrence of cardiovascular mortality for 4 weeks.?Nineteen (7.2%) patients died during the 4 weeks.?The admission levels of IL-6 were significantly higher in patients who died from cardiovascular causes, whereas?sICAM-1,?sVCAM-1, and sP-selectin were not. Kaplan–Meier plots demonstrated a significant increase in cardiovascular mortality with increasing IL-6 levels (P = 0.0060). Logistic regression analysis revealed that IL-6 was an independent predictor for cardiovascular mortality. The present study indicates that elevated admission level of IL-6 but notsoluble adhesion molecules?could provide valuable information for short-term risk stratification in patients with STEMI.
机译：炎症反应是动脉粥样硬化过程各个阶段的重要组成部分。这种认识刺激了人们对不同炎症标记物作为心血管风险潜在预测因子的评估。本研究旨在同时测量血清白细胞介素-6（IL-6），“可溶性细胞间粘附分子-1”（sICAM-1），可溶性血管细胞粘附分子-1“ sVCAM-1”和“血清”水平。急性ST段抬高型心肌梗死（STEMI）患者中使用可溶性P-选择素（sP-selectin）并评估其预测短期预后的能力。我们招募了263名在6小时内入院的连续患者症状发作，首先诊断为STEMI。记录临床数据并测量血清IL-6，sICAM-1，sVCAM-1和sP-选择素的水平。然后对患者进行前瞻性随访，观察其发生心血管疾病的死亡率为4周。4周内有19名患者（7.2％）死亡。 sICAM-1，？sVCAM-1和sP-选择素则不是。 Kaplan–Meier图显示，随着IL-6水平的升高，心血管死亡率显着增加（P = 0.0060）。 Logistic回归分析显示，IL-6是心血管疾病死亡率的独立预测因子。本研究表明，IL-6的入院水平升高但不溶性粘附分子可能为STEMI患者的短期危险分层提供有价值的信息。

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