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首页> 外文期刊>African Journal of Biotechnology >Anti-inflammatory, anti-proliferative and anti-oxidant activities of organic extracts from the Mediterranean seaweed, Cystoseira crinita
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Anti-inflammatory, anti-proliferative and anti-oxidant activities of organic extracts from the Mediterranean seaweed, Cystoseira crinita

机译：地中海海藻Cystoseira crinita的有机提取物的抗炎，抗增殖和抗氧化活性

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摘要

This study was conducted to evaluate the anti-inflammatory, the anti-proliferative, total phenolic content (TPC) and the anti-oxidant activity of the chloroformic (CHCl3), the ethyl acetate (AcOEt) and the methanolic (MeOH) extracts of?Cystoseira crinita. These extracts were assayed on carrageenan induced rat paw oedema assay. They exhibited significant anti-inflammatory activity in a dose dependent manner. The anti-proliferative activity of organic extracts of?C. crinita?was evaluated on cancer cell lines (A549, MCF7 and HCT15) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. CHCl3?and AcOEt extracts showed important anti-proliferative activity against both HCT15 and MCF7 cell lines. Organic extracts of?C. crinitashowed important TPC. Moreover, they exhibited significant radical scavenging activity and displayed the highest reducing power. Organic extracts of?C. crinita?might be used as a significant potential source of natural compounds with anti-inflammatory, anti-proliferative and anti-oxidant activity. It could have a promising role in future medicine.
机译：进行这项研究是为了评估氯仿（CHCl3），乙酸乙酯（AcOEt）和甲醇（MeOH）提取物的抗炎，抗增殖，总酚含量（TPC）和抗氧化活性。 Cystoseira crinita。这些提取物在角叉菜胶诱导的大鼠爪水肿测定中进行测定。它们以剂量依赖性方式表现出显着的抗炎活性。 ？C有机提取物的抗增殖活性。通过3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四氮唑（MTT）分析法对癌细胞系（A549，MCF7和HCT15）评估了crinita?。 CHCl3和AcOEt提取物对HCT15和MCF7细胞系均显示出重要的抗增殖活性。 C的有机提取物。 crinita展示了重要的TPC。此外，它们表现出显着的自由基清除活性并显示出最高的还原能力。 C的有机提取物。可能被用作具有抗炎，抗增殖和抗氧化活性的天然化合物的重要潜在来源。它可能在未来的医学中扮演有希望的角色。

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