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首页> 外文期刊>African Journal of Biotechnology >Anti-hyperlipidemic and biochemical effect of extract of Tulbaghia violacea rhizomes on high cholesterol diet fed rats
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Anti-hyperlipidemic and biochemical effect of extract of Tulbaghia violacea rhizomes on high cholesterol diet fed rats

机译：紫茎泽兰提取物对高胆固醇饮食喂养大鼠的降血脂和生化作用

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摘要

Anti-hyperlipidemic and biochemical effect of methanolic extract of?Tulbaghia?violacearhizomes were investigated in cholesterol rich diet-induced hypercholesterolemia Wistar albino rats. Hypercholesterolemia was induced in rats by feeding with 2% cholesterol rich diet (high cholesterol diet, HCD) for four weeks. Some biochemical parameters and histology of the liver were assessed following 28 days oral treatment. Co-administration of extract of?T. violacea?rhizomes at 250 and 500 mg/kg respectively, significantly (p<0.05) protected against hypercholesterolemia induced alanine amino transferase (ALT) alterations in activities of serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), gamma glutamyl transferase (gGT), total cholesterol, triglycerides, albumin and total protein in a dose dependent manner. The extract also caused significant (p<0.05) increase in high density lipoprotein (HDL)-cholesterol level. Anti-cholesterolemic and hepatoprotective effect of the extract at both doses were comparable and similar to that of the standard treatment of atorvastatin (30 mg/kg body weight). Histological examination of the liver showed that the extract markedly protected against hypercholesterolemia induced micro-vesicular steatosis. This study suggests that?T. violacea?rhizome extract may protect against hypercholesterolemic induced diseases and this may account for its folklore usage.
机译：在富含胆固醇的饮食诱导的高胆固醇血症Wistar白化病大鼠中，研究了“塔尔巴希亚（Tulbaghia）”-violacearhizomes甲醇提取物的抗高脂血症和生化作用。高胆固醇血症是通过喂食2％富含胆固醇的饮食（高胆固醇饮食，HCD）持续4周而诱发的。口服治疗28天后，评估了肝脏的一些生化参数和组织学。 T提取物的共同给药。分别以250和500 mg / kg的violacea？rhizomes抑制（p <0.05）高胆固醇血症诱导的血清天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT）和碱性磷酸酶（ALT）的丙氨酸氨基转移酶（ALT）改变ALP），总胆红素（TB），乳酸脱氢酶（LDH），γ-谷氨酰转移酶（gGT），总胆固醇，甘油三酸酯，白蛋白和总蛋白呈剂量依赖性。提取物还引起高密度脂蛋白（HDL）-胆固醇水平显着（p <0.05）升高。两种剂量提取物的抗胆固醇和肝保护作用均与阿托伐他汀的标准治疗（30 mg / kg体重）相当。肝脏的组织学检查表明，该提取物可明显防止胆固醇过多引起的微泡脂肪变性。这项研究表明？紫薇根茎提取物可以预防高胆固醇血症引起的疾病，这可能是民间传说的使用原因。

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