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首页> 外文期刊>African Journal of Biotechnology >Obestatin induces testosterone secretion from rat testis in vitro
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Obestatin induces testosterone secretion from rat testis in vitro

机译：Obestatin体外诱导大鼠睾丸分泌睾丸激素

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摘要

In this study, the effect of obestatin (23 amino acid peptide) on testosterone secretion?in vitro, in the rat testis was observed. For this purpose, two different doses of obestatin (10-9?M and 10-8?M) were used alone and in combination with human chorionic gonadotropin (hCG) in fasting and fed conditions in two age groups. Fasting induced a significant reduction in body weight (p < 0.05) and plasma testosterone concentrations (0.001). hCG stimulated testosterone secretions were significantly (p < 0.05) high as compared to the basal control testosterone concentrations after 90 min in some groups and 180 min of incubation in all groups. Obestatin at the dose of 10-9?M alone and in combination with hCG failed to change testosterone concentrations in all groups; however, 10-8?M obestatin significantly (p < 0.05) induced hCG stimulated testosterone concentrations in both normally fed pre-pubertal and adult rats. No significant difference was noticed in 48 h fasted groups. This data suggests that, obestatin is a positive modulator of testosterone secretion and its effect depends upon the nutritional status of the body.
机译：在这项研究中，观察到了肥胖抑制素（23个氨基酸的肽）对大鼠睾丸体外睾丸激素分泌的影响。为此目的，在两个年龄组的禁食和进食条件下，单独使用两种不同剂量的Obestatin（10-9？M和10-8？M），并与人绒毛膜促性腺激素（hCG）结合使用。空腹导致体重（p <0.05）和血浆睾丸激素浓度（0.001）显着降低。在某些组中90分钟后和所有组中孵育180分钟后，与基础对照睾丸激素浓度相比，hCG刺激的睾丸激素分泌量显着（p <0.05）高。单独使用10-9？M剂量的Obestatin并与hCG结合后，所有组的睾丸激素浓度均无变化。然而，在正常喂养的青春期前和成年大鼠中，10-8？M抑素都显着（p <0.05）诱导了hCG刺激的睾丸激素浓度。禁食48 h组未发现明显差异。该数据表明，肥胖抑制素是睾丸激素分泌的正调节剂，其作用取决于身体的营养状况。

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