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首页> 外文期刊>African Journal of Biotechnology >Attenuation of cisplatin-induced nephrotoxicity in rats using zerumbone
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Attenuation of cisplatin-induced nephrotoxicity in rats using zerumbone

机译：蛇骨素减轻顺铂引起的大鼠肾毒性

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Zerumbone is a natural compound?isolated from the fresh rhizomes of?Zingiberzerumbet. This bioactive compound has shown a chemo-preventive, anti-inflammatory and free radical scavenging activities. This study examines the effect of zerumbone on the extent of tissue damage in cisplatin-induced nephrotoxicity in rats. The rats received a single dose injection of 10 mg/kg cisplatin. Other groups of rats received zerumbone (100 and 200 mg/kg), corn oil or the vehicle, dimethyl sulfoxide (DMSO) intraperitoneally for 4 days prior to cisplatin-injections. All animals were decapitated 16 h after cisplatin injection. Trunk blood was collected and analyzed for blood urea nitrogen (BUN) and serum creatinine. Kidney tissue was kept for the quantification of malondialdehyde and glutathione levels. Histopathological investigations were carried out and the severity of lesions was scored to obtain quantitative data. Our study revealed that zerumbone reduced kidney damage and preserved renal functions as proved by microscopic observations and lesion scoring. The increased in kidney malondialdehyde (MDA) levels with simultaneous glutathione (GSH) reduction in cisplatin treated group was attenuated by zerumbone (p < 0.05). It was concluded that zerumbone is beneficial in cisplatin-induced renal dysfunction and organ damage in rats possibly via the prevention of lipid per oxidation and preservation of antioxidant glutathione.
机译：Zerumbone是一种天然化合物，是从Zingiberzerumbet的新鲜根茎中分离出来的。这种生物活性化合物已显示出化学预防，抗炎和清除自由基的活性。这项研究探讨了采鲁骨对顺铂诱导的大鼠肾毒性组织损伤程度的影响。大鼠接受单剂10 mg / kg顺铂注射。其他组的大鼠在顺铂注射前4天腹膜内接受泽仑骨（100和200 mg / kg），玉米油或赋形剂，二甲基亚砜（DMSO）。顺铂注射后16小时，所有动物断头。收集躯干血液，并分析血液中的尿素氮（BUN）和血清肌酐。保留肾脏组织以定量丙二醛和谷胱甘肽水平。进行组织病理学研究，并对病变的严重程度进行评分以获得定量数据。我们的研究表明，如通过显微镜观察和病变评分所表明的，蛇骨酮可减少肾脏损害并保留肾脏功能。齐鲁宾治疗组可减轻肾脏丙二醛（MDA）水平的增加，同时减少谷胱甘肽（GSH）的效果（p <0.05）。得出的结论是，zerumbone可能通过预防脂质过氧化和保存抗氧化剂谷胱甘肽对顺铂引起的大鼠肾功能障碍和器官损伤有益。

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