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首页> 外文期刊>African Journal of Biotechnology >Toxicological effects of arsenic exposure in a freshwater teleost fish, Channa punctatus
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Toxicological effects of arsenic exposure in a freshwater teleost fish, Channa punctatus

机译：淡水硬骨鱼Channa punctatus中砷暴露的毒理作用

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High concentration of arsenic in groundwater in the north-eastern states of India has become a major cause of concern.?Inorganic arsenic?of geological origin is found in?groundwater?used as drinking-water in several parts of the world. Arsenic is used in various industries and agriculture and excessive arsenic finds its way into lakes and rivers. Since arsenic is a known human carcinogen, the epidemiological studies are extremely important for this metal. Fish are ideal organisms to work with in toxicogenomics studies due to the strong power of fish models to establish biomarkers of exposure. Since, fishes respond to toxicants in a similar way as higher vertebrates, they can be used to screen for chemicals that are potentially teratogenic and carcinogenic to humans. Also fish absorbs dissolved or available metals and therefore can serve as indicator of metal pollution. The objectives of this work were to examine the toxicological effect and molecular changes caused by a heavy metal sodium arsenite (NaAsO2), in?Channa punctatus. When fishes were exposed to NaAsO2, it induced death of the fishes in a concentration-dependent manner. 100 ppm, the highest concentration tested in this study, was found to be the deadliest and it induced death of the fishes within 18 to 20 h. As the concentration lowered the survival time increased dose dependently. Liver is the target organ of arsenic toxicity. Fish liver plays an important role in uptake, accumulation, bio-transformation and excretion of arsenic. We investigated the effect of NaAsO2?on fish liver. NaAsO2?was found to cause liver chromosomal DNA fragmentation and expression of certain proteins.
机译：印度东北各州地下水中砷的高浓度已成为引起人们关注的一个主要原因。在世界上许多地方，被用作饮用水的“地下水”中发现了具有地质起源的无机砷。砷用于各种工业和农业，过量的砷进入湖泊和河流。由于砷是已知的人类致癌物，因此流行病学研究对于这种金属极为重要。鱼是毒理基因组学研究中理想的有机体，因为鱼模型具有强大的能力来建立暴露的生物标记。由于鱼类对毒物的反应方式与高级脊椎动物相似，因此可用于筛选可能对人类致畸和致癌的化学物质。鱼也吸收溶解的或可利用的金属，因此可以作为金属污染的指标。这项工作的目的是要检查点缀Channa punctatus的重金属亚砷酸钠（NaAsO2）的毒理作用和分子变化。当鱼类暴露于NaAsO2时，会以浓度依赖性方式导致鱼类死亡。这项研究中测试的最高浓度100 ppm被发现是最致命的，它在18至20 h内导致鱼类死亡。随着浓度降低，存活时间依赖于剂量增加。肝脏是砷毒性的靶器官。鱼肝在砷的吸收，积累，生物转化和排泄中起着重要作用。我们调查了NaAsO2？对鱼肝的影响。已发现NaAsO 2引起肝脏染色体DNA断裂和某些蛋白质的表达。

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