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首页> 外文期刊>African Journal of Biotechnology >The effect of CoQ10 and vitamin E on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals in rats induced with doxorubicin
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The effect of CoQ10 and vitamin E on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals in rats induced with doxorubicin

机译：辅酶Q10和维生素E对阿霉素致大鼠血清总唾液酸，脂质结合唾液酸，微量元素和矿物质的影响。

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摘要

This study was designed to evaluate the effect of CoQ10?and vitamin E on serum total sialic acid (TSA), lipid bound sialic acid (LSA) and some elements in rat administered doxorubicin (DXR). Cu levels were increased in the group treated with DXR + vitamin E in comparison with DXR (p<0.05) and CoQ10?groups (p = 0.001). Furthermore, copper levels were increased in the group treated with DXR + CoQ10?in comparison with CoQ10?group (p < 0.05). Zn levels were decreased in the group treated with DXR + vitamin E in comparison with CoQ10?group (p < 0.05). Mg levels were decreased in subjects treated with DXR + vitamin E in comparison with the control group values (p < 0.05). Particularly, the observed increase in Cu levels in rats from DXR + vitamin E group might be due to the decrease of vitamin E. However, the oxidative damage could be as a result of DXR occurence and may be helpful to clinicians in chemotherapy using anthracycline.
机译：本研究旨在评估辅酶Q10和维生素E对大鼠施用阿霉素（DXR）的血清总唾液酸（TSA），脂质结合唾液酸（LSA）和某些元素的影响。与DXR组（p <0.05）和CoQ10？组（p = 0.001）相比，用DXR +维生素E处理的组中的铜含量增加。此外，与辅酶Q10？组相比，用DXR +辅酶Q10？处理的组中的铜水平增加了（p <0.05）。与辅酶Q10？组相比，用DXR +维生素E治疗的组中的锌水平降低了（p <0.05）。与对照组相比，用DXR +维生素E治疗的受试者的Mg水平降低（p <0.05）。特别是，观察到的DXR +维生素E组大鼠的Cu水平升高可能是由于维生素E减少所致。但是，氧化损伤可能是DXR的结果，可能对使用蒽环类药物进行化学疗法的临床医生有所帮助。

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