Genetic determinants of antifungal resistance in Candida species

Danielly Beraldo dos Santos Silva; Alexéia Barufatti Grisolia; Kelly Mari Pires de Oliveira

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Genetic determinants of antifungal resistance in Candida species

机译：念珠菌抗真菌抗性的遗传决定因素

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In the previous decades, it has been an increase in cases of resistance to antifungal agents used in the prophylaxis and treatment of infections caused by Candida species. The emergence of resistance to drug classes, it is usually explained by genome alterations ranging from point mutations to gain or loss of whole chromosomes. Therefore, identify and understand into the molecular mechanisms that underlie resistance of the Candida spp. is important because this information can provide appropriate treatments in emergency candidemia cases. In this sense, this review have the aim of discuss about the genetic variations associated the antifungal resistance in Candida spp.

机译：在过去的几十年中，用于预防和治疗由念珠菌引起的感染的抗真菌剂的耐药性有所增加。对药物类别的抗药性的出现，通常可以通过基因组改变来解释，从点突变到整个染色体的增减。因此，确定并了解构成念珠菌抗性的分子机制。之所以重要，是因为该信息可以在紧急候选念珠菌病例中提供适当的治疗。从这个意义上讲，本综述旨在讨论与念珠菌抗真菌性相关的遗传变异。

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《African Journal of Biotechnology》 |2016年第40期|共6页
作者
Danielly Beraldo dos Santos Silva; Alexéia Barufatti Grisolia; Kelly Mari Pires de Oliveira;
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中图分类生物工程学（生物技术）;
关键词
Antifungal agentscandidiasismolecular characterizationmutationsoverexpression;

机译：抗真菌剂念珠菌分子特征突变过表达;

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1. Species distribution and antifungal resistance profiles among Candida species isolated from invasive Candida infections in a Turkish university hospital [J] . Baris A., Turan D., Sav H., Mycoses: Diagnosis, therapy and prophylaxis of fungal diseases . 2015,第Suppla4期

机译：在一家土耳其大学医院中，从侵袭性念珠菌感染中分离出的念珠菌中，细菌的种类分布和抗真菌特性
2. Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris [J] . Jeffrey M. Rybak, José F. Mu?oz, Katherine S. Barker, MBio . 2020,第3期

机译：<斜视> TAC1B 中的突变：<命名含量含量型=“属型”> Candida auris 中的新型遗传决定蛋白抗性
3. Impact of New Antifungal Breakpoints on Antifungal Resistance in Candida Species [J] . Annette W. Fothergill, Deanna A. Sutton, Dora I. McCarthy, Journal of Clinical Microbiology . 2014,第3期

机译：新的抗真菌断点对念珠菌抗真菌性的影响
4. Effect of antifungal agents on non-Candida albicans Candida species enzymatic activity [C] . M. Negri, T. Loren?o, S. Silva, International Conference on Antimicrobial Research . 2011

机译：抗真菌剂对非念珠菌白醛念珠菌物种酶活性的影响
5. Emergence of Multidrug Cross-Resistance Between Agricultural and Human Antifungals in Clinically Relevant Species of Aspergillus and Candida [D] . Antunes, Isabel Cristina Santos Silva de Faria Ramos. 2018

机译：在临床上与曲霉菌和念珠菌有关的物种中，农业和人类抗真菌药之间出现了多种药物交叉耐药性。
6. Evaluation of Molecular Epidemiology Clinical Characteristics Antifungal Susceptibility Profiles and Molecular Mechanisms of Antifungal Resistance of Iranian Candida parapsilosis Species Complex Blood Isolates [O] . Amir Arastehfar, Farnaz Daneshnia, Mohammad Javad Najafzadeh, 2020

机译：伊朗假丝酵母念珠菌复杂血液分离株的分子流行病学临床特征抗真菌药性概况和抗真菌耐药性分子机制的评估
7. Effect of initial antifungal therapy on mortality among patients with bloodstream infections with different Candida species and resistance to antifungal agents: A multicentre observational study by the Turkish Fungal Infections Study Group [O] . Özlem Doğan, Ayşegül Yeşilkaya, Şirin Menekşe, 2020

机译：初始抗真菌治疗血流感染不同念珠菌物种和抗真菌剂抗性患者死亡率的影响：土耳其真菌感染研究组的多期视察研究

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Genetic determinants of antifungal resistance in Candida species

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