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首页> 外文期刊>African Journal of Biotechnology >Antibacterial potential of silver nanoparticle synthesized by marine actinomycetes in reference with standard antibiotics against hospital acquired infectious pathogens
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Antibacterial potential of silver nanoparticle synthesized by marine actinomycetes in reference with standard antibiotics against hospital acquired infectious pathogens

机译：海洋放线菌结合标准抗生素合成的银纳米颗粒对医院获得性传染病原菌的抗菌潜力

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Multi resistance to antibiotics is a serious and disseminated clinical problem, common to several new compounds that block the resistance mechanism. The present study aimed at the comparative study of silver nanoparticles synthesized through actinomycetes and their antimicrobial metabolites with standard antibiotic. Marine actinomycetes collected from Gulf mannar costal region, Kayalpatnam, located at Tuticorin district, Tamil nadu, India. Totally, five actinomycetes were isolated and identified based on their spore formation and biochemical studies. Three isolates belonged to the genera of Streptomyces sp and two were Micromonospora sp. Streptomyces sp KPMS3 showed potent antibacterial activity against Gram negative pathogens. Gram positive isolates are sensitive to Micromonospora sp (KPMM2). Among the five isolates, isolate Micromonospora sp (KPMM2) was found to be an effective silver nanoparticle synthesizer. The obtained silver nanoparticles were characterized using UV-Vis spectroscopy, FTIR and TEM. The morphology of nanoparticle is found to be spherical and an average size of ranges between 38 to 52 nm. The antimicrobial activities of silver ion against test pathogens were found to be superior to cephalosporin antibiotic. The in vitro hemolytic assessment of silver nanoparticles were found to be non-hemolytic at maximum of 20 μg/ml. It was found that smaller silver nanoparticles synthesized by microbial route had a greater antibacterial activity and less hemolytic in nature.
机译：对抗生素的多重耐药是一个严重且分散的临床问题，这是几种阻断耐药机制的新化合物所共有的。本研究旨在通过放线菌及其抗菌代谢物与标准抗生素合成银纳米颗粒的比较研究。海洋放线菌是从位于印度泰米尔纳德邦杜蒂戈林区的卡纳帕特南海湾马纳尔沿海地区采集的。根据它们的孢子形成和生化研究，总共分离并鉴定了五种放线菌。三个分离株属于链霉菌属，两个是微单孢菌属。链霉菌KPMS3对革兰氏阴性病原体显示出强大的抗菌活性。革兰氏阳性分离株对Micromonospora sp（KPMM2）敏感。在这五个分离株中，分离株Micromonospora sp（KPMM2）被发现是一种有效的银纳米颗粒合成仪。使用UV-Vis光谱，FTIR和TEM表征获得的银纳米颗粒。发现纳米颗粒的形态为球形，并且平均尺寸在38至52nm之间。发现银离子对测试病原体的抗菌活性优于头孢菌素抗生素。银纳米颗粒的体外溶血评估发现最大20μg/ ml是非溶血的。发现通过微生物途径合成的较小的银纳米颗粒具有更大的抗菌活性并且本质上具有更少的溶血作用。

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