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首页> 外文期刊>African Journal of Biotechnology >The effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin E
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The effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin E

机译：丙戊酸对妊娠大鼠肾小球的影响以及叶酸和维生素E的保护作用

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We aimed to investigate the potential harmful effects of valproic acid (VPA), ?a widely used anticonvulsant in child delivery, and the protective effects of vitamin E (Vit E) and folic acid (FA) on kidney. Sodium valproate (400 mg/kg), folic acid (400 mg/kg) and vitamin E (250 mg/kg) were administered to rats on each of gestation days, 8?th, 9?th, and 10?th. The rats were sacrificed on the 20?th?day of pregnancy. With thin sections of kidney biopsies, they were stained with uranyl acetate-lead citrate and examined under transmission electron microscope. The?animals were divided into four groups randomly:?control, VPA, VPA+FA and VPA+Vit E groups. In each group, drug procedure, surgical procedure and histological methods were performed. The histopathological findings of control group was normal. In VPA group, it showed degenerative changes especially in renal glomerular basal membrane and foot process. Both VPA+FA and VPA+Vit E groups exhibited similar ultrastructural changes and had almost the normal structure. Administration of single doses of SV (400 mg/kg) resulted in degenerative changes on kidney at ultrastructural level. Administration of FA and Vit E had a protective effect by preventing the degenerative changes to a certain degree. The aim of the present study is to examine histopathologic changes which may occur in a high risk experimental model after the administration of valproic acid. In addition, protective roles of the administration of folic acid and vitamin E are assessed.
机译：我们旨在研究丙戊酸（VPA）（一种在分娩中广泛使用的抗惊厥药）的潜在有害作用，以及维生素E（Vit E）和叶酸（FA）对肾脏的保护作用。在妊娠第8、9和10天的每一天，分别给大鼠服用丙戊酸钠（400 mg / kg），叶酸（400 mg / kg）和维生素E（250 mg / kg）。在妊娠第20天处死大鼠。肾脏活组织检查薄切片，用醋酸铀酰-柠檬酸铅染色，并在透射电子显微镜下检查。将动物随机分为四组：对照组，VPA，VPA + FA和VPA + Vit E组。在每组中，进行药物处理，外科手术处理和组织学方法。对照组的组织病理学检查正常。在VPA组中，它表现出退行性变化，尤其是在肾小球基底膜和足突中。 VPA + FA和VPA + Vit E组均表现出相似的超微结构变化，并且几乎具有正常结构。单剂量SV（400 mg / kg）的使用导致肾脏在超微结构水平上的退行性改变。 FA和Vit E的给药通过在一定程度上防止退行性变化而具有保护作用。本研究的目的是检查在服用丙戊酸后高风险实验模型中可能发生的组织病理学变化。此外，还评估了叶酸和维生素E给药的保护作用。

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