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首页> 外文期刊>African Journal of Biotechnology >Antioxidant and antimutagenic activities of Viscum album fruit ethanolic extract in human lymphocytes
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Antioxidant and antimutagenic activities of Viscum album fruit ethanolic extract in human lymphocytes

机译：洋蓟果实乙醇提取物对人淋巴细胞的抗氧化和诱变活性。

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摘要

Polyphenolic compounds are widely distributed in plants and known to be excellent antioxidants?in vitro. They have the capacity to reduce free-radical formation by scavenging free-radicals. In this study we have evaluated the antioxidant and antimutagenic potencies of polyphenolic compounds of?Viscum album?against trichloroethylene (TCE)-induced oxidative and genotoxic damage.?V. album?extract (VAE 0.5 μg/ml) protected human lymphocytes against TCE. In chromosomal aberration (CA) analysis, no significant increase in total aberrations were found after treatment with TCE and all VAE concentrations. The mitotic index (MI) showed significant increase in 0.5 μg/ml VAE samples when compared with TCE-treated (2 μM) group. VAE (0.5 μg/ml) reduced the levels of malondialdehyde (MDA) significantly wherease VAE (1.0 and 2.0 μg/ml) samples increased MDA concentrations significantly. We have also shown that the various DNA effects of TCE treatment seem to be DNA damages, but not mutations as TCE treated profiles were reverted back to the control like profiles by most probably DNA repair mechanisms in VAE 0.5 μg/ml treated group.
机译：多酚类化合物广泛分布于植物中，在体外已知是极好的抗氧化剂。它们具有通过清除自由基来减少自由基形成的能力。在这项研究中，我们评估了“ Viscum album”多酚化合物对三氯乙烯（TCE）诱导的氧化和遗传毒性损害的抗氧化和抗诱变能力。白蛋白提取物（VAE 0.5μg/ ml）保护了人的淋巴细胞抗TCE。在染色体畸变（CA）分析中，用TCE和所有VAE浓度处理后，总畸变均未发现明显增加。与TCE处理（2μM）组相比，有丝分裂指数（MI）在0.5μg/ ml VAE样品中显示出显着增加。 VAE（0.5μg/ ml）显着降低了丙二醛（MDA）的水平，而VAE（1.0和2.0μg/ ml）样品显着提高了MDA浓度。我们还显示，TCE处理的各种DNA效应似乎是DNA损伤，但不是突变，因为在VAE 0.5μg/ ml处理组中，TCE处理的图谱很可能通过DNA修复机制恢复为对照样图谱。

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