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Schwann cells promote neuronal differentiation of bone marrow stromal cells

机译:雪旺氏细胞促进骨髓基质细胞的神经元分化

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Bone marrow stromal cells (BMSCs),?a type of multipotent stem cell, can differentiate into various types of cells. It has been suggested that the BMSCs have the capacity to differentiate into neurons?under specific experimental conditions, using chemical factors. In this study, we showed that?BMSCs?can be induced to differentiate into neuron-like cells when they are co-cultured with Schwann cells byBrdu pulse label technology. It was found that?a large scale of?BMSCs?showed a typical neuronal morphology and axon extended about 10 day after beginning of co-culture. These findings support the transdifferentiation of?BMSCs, and the theoretical utility of these cells for the treatment of degenerative and acquired disorders of the nervous system and spinal cord injury.?Key word:?Bone marrow stromal cells, Schwann cells, co-cultured, Brdu pulse label, axon, differentitation.
机译:骨髓基质细胞(BMSC)是一种多能干细胞,可以分化为各种类型的细胞。有人提出,在特定的实验条件下,利用化学因子,骨髓间充质干细胞具有分化为神经元的能力。在这项研究中,我们表明,通过Brdu脉冲标记技术将BMSCs与Schwann细胞共培养时,可以诱导BMSCs分化为神经元样细胞。发现在共培养开始后约10天,大量的“ BMSC”表现出典型的神经元形态,并且轴突延长。这些发现支持了BMSCs的转分化作用,以及这些细胞在治疗神经系统退行性和后天性疾病以及脊髓损伤方面的理论实用性。 Brdu脉冲标签,轴突,分化。

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