• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>African Journal of Cellular Pathology >Effect of highly active antiretroviral therapy (haart) on cd4+ cell count and liver enzymes in HIV infection at Lokoja, Nigeria
【24h】

Effect of highly active antiretroviral therapy (haart) on cd4+ cell count and liver enzymes in HIV infection at Lokoja, Nigeria

机译：尼日利亚洛科贾高效抗逆转录病毒疗法（haart）对HIV感染中cd4 +细胞计数和肝酶的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution.Methods: A cohort of 200 (66 males, 134 females) consenting HAART na?ve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by Western blot method) at Lokoja, Nigeria having a baseline CD4 + cell counts ≤350 cells/μL were initiated on HAART for six months. Two blood samples were collected, one at pre-HAART (baseline) and the other at post-HAART (follow-up) phase. CD4 + cells were counted and liver enzymes levels were evaluated using the Partec? Cyflow Counter and Reflotron? Plus Auto-Analyzer, respectively.Results: The immunological outcome of 6 months HAART shows that there was slight increase (statistically, considered not significant, P>0.05) in the post-HAART mean±SEMCD4 + cell count in the different age and sex strata investigated, when comparison was made with the pre-HAART mean±SEMCD4 + cell count. Also, the post HAART liver function test show that the liver enzymes levels were not significantly (P>0.05) elevated when compared to the baseline values.Conclusion: Six months of HAART repleted CD4 + cell counts of HIV-infected patients of different age and sex strata, with no risk of liver damage.Keywords: HIV, HAART, Immune response, CD4 + cell, Liver enzymes.
机译：目的：根据治疗前后六个月的年龄和性别分布，评估高活性抗逆转录病毒疗法（HAART）对感染HIV的患者CD4 +细胞计数和肝酶的影响。方法：队列研究200名患者（66名男性，134名患者）女性）同意接受HAART初治的患者，年龄在16至65岁之间，在尼日利亚洛科贾确诊为HIV感染病例（通过Western印迹法），基线CD4 +细胞计数≤350细胞/μL，开始接受HAART治疗六个月。收集了两个血液样本，一个在HAART前（基线），另一个在HAART后（随访）。使用Partec？对CD4 +细胞计数并评估肝酶水平。 Cyflow计数器和Reflotron？结果：6个月HAART的免疫学结果显示，不同年龄和性别的HAART后平均值±SEMCD4 +细胞计数略有增加（统计学上认为不显着，P> 0.05）。与HAART前平均值±SEMCD4 +细胞计数进行比较时，对所调查的阶层进行了调查。此外，HAART后的肝功能测试显示，与基线值相比，肝酶水平没有显着升高（P> 0.05）。结论：六个月的HAART补充了不同年龄和年龄的HIV感染患者的CD4 +细胞计数关键词：HIV，HAART，免疫反应，CD4 +细胞，肝酶。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号