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Common artifacts and remedies in histopathology (a review)

机译:组织病理学中常见的人工制品和补救措施(综述)

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The essence of preparing a biological specimen for microscopic studies is to get adequate and accurate medical information that is a true representation of the specimen, be it for research or diagnostic purposes. An artifact can be defined as unrelated, self-colored artificial feature found in tissue sections. This has been an age long cause of misinterpretation leading to misdiagnosis to microscopists. The processing of specimen for medical information is subject to a procedure that results in a tissue fit for diagnosis and interpretation. The procedures themselves are subject to human and material errors and the result is an artifact that in the least may interfere with adequate diagnosis or at the most render the tissue so distorted as to be undiagnosable. The need to recognize these artifacts and attempt to overcome them is the single biggest challenge in the histopathology Laboratory. This article focused on identifying artifacts and their potential cause so that misinterpretation and difficulty in diagnosis can be overcome, and help microscopist to come into definite diagnosis.Keywords: Artifacts, Histopathologist, Microscopist, Diagnosis.
机译:准备用于显微镜研究的生物标本的本质是获得足够和准确的医学信息,这些信息可以真实地代表标本,无论是用于研究还是用于诊断目的。伪影可以定义为在组织切片中发现的不相关的自着色人工特征。这是长期以来引起误解的原因,导致对显微镜医师的误诊。用于医疗信息的标本的处理要遵循导致组织适合于诊断和解释的程序。程序本身容易受到人为和物质错误的影响,其结果是一种假象,其至少会干扰适当的诊断,或者至多会使组织变形至无法诊断的程度。认识到这些伪影并试图克服它们是组织病理学实验室面临的最大挑战。本文着重于识别伪影及其潜在原因,以便克服误解和诊断困难,并帮助显微医师进行明确的诊断。关键字:伪影,组织病理学家,显微医师,诊断。

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