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首页> 外文期刊>African Journal of Biotechnology >Blood pressure lowering effect of Tylophora hirsuta wall
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Blood pressure lowering effect of Tylophora hirsuta wall

机译：Tylophora hirsuta壁的降血压作用

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Crude hydromethanolic extract of?Tylophora hirsuta?(Th.Cr) was studied in spontaneous hypertensive Wistar rats for possible effects on high blood pressure and heart rate. In the absence of atropine, fall in arterial blood pressure was 64±7 mmHg at the dose of 100 mg/kg while in the presence of atropine, there was no effect on arterial blood pressure suggesting cholinergic receptor blockade. Fall in heart rate, in the absence of atropine, was 218±8 beats per minute (BPM) while, fall in heart rate, in the presence of atropine was 110±5.6 BPM, indicating that the action is through cholinergic muscarinic receptors as atropine is?a?typical anticholinergic drug. The percent fall in blood pressure and heart rate were standardized versus acetylcholine; standard cholinergic drug. Th.Cr tested mildly positive for alkaloids, flavonoids and strongly positive for terpenes and terpenoids, and saponins.?α-?Amyrin acetate was isolated from the?n-hexane fraction of Th.Cr for the first time from?T. hirsuta. The results confirm the presence of acetylcholine like substances in?T. hirsuta?that provide a basis for its traditional use in treatment of hypertension. The action may be attributed to the phytochemicals like flavonoids, saponins, terpenes and terpenoids and?α- amyrin acetate isolated for the first time from the plant.
机译：研究了自发性高血压Wistar大鼠的粗毛水提香（Tylophora hirsuta）（Th.Cr）对高血压和心率的影响。在没有阿托品的情况下，剂量为100 mg / kg时，动脉血压下降为64±7 mmHg，而在存在阿托品的情况下，对动脉血压没有影响，提示胆碱能受体阻滞。在没有阿托品的情况下，心率下降为每分钟218±8次（BPM），而在存在阿托品的情况下，心率下降为110±5.6 BPM，这表明该作用是通过胆碱能毒蕈碱受体如阿托品是一种典型的抗胆碱药。相对于乙酰胆碱，标准化了血压和心率的下降百分比;标准胆碱能药。 Th.Cr的生物碱，类黄酮类化合物呈轻度阳性，而萜类，萜类化合物和皂苷呈强阳性。首次从ΔT中从Th.Cr的正己烷馏分中分离出α-α-胰岛淀粉糊精乙酸盐。 hirsuta。结果证实在ΔT中存在乙酰胆碱样物质。 hirsuta？为其传统治疗高血压提供基础。该作用可归因于首次从植物中分离出的植物化学物质，如类黄酮，皂角苷，萜烯和萜类化合物以及乙酸α-α-myrin。

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