Comparative study of biological activity of glutathione, sodium tungstate and glutathione-tungstate mixture

Arshad Farid; Abdul Haleem Shah; Muhammad Ayaz; Adnan Amin Muhammad Yaseen; Hafeez Ullah; Fazal Haq

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Comparative study of biological activity of glutathione, sodium tungstate and glutathione-tungstate mixture

机译：谷胱甘肽，钨酸钠和谷胱甘肽-钨酸盐混合物的生物活性比较研究

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Glutathione (GSH) and sodium tungstate (Na2WO4) are important pharmacological agents. They provide protection to cells against cytotoxic agents and thus reduce their cytotoxicity. It was of interest to study the biological activity of these two pharmacological active agents. Different strains of bacteria were used and the zone of inhibition was determined for GSH, Na2WO4?and GSH+ Na2WO4?mixture. The results show high antibacterial activity of GSH as compared to Na2WO4 and Na2WO4+GSH mixture. It was observed that GSH antibacterial activity was significantly lowered upon addition of Na2WO4?to GSH aqueous solution. The results conclude with the proposed formation of W-SG complex in aqueous solution.

机译：谷胱甘肽（GSH）和钨酸钠（Na2WO4）是重要的药理剂。它们为细胞提供抗细胞毒性剂的保护，从而降低其细胞毒性。研究这两种药理活性剂的生物活性是令人感兴趣的。使用不同的细菌菌株，并确定了GSH，Na2WO4α和GSH +Na2WO4β混合物的抑制区域。结果表明，与Na2WO4和Na2WO4 + GSH混合物相比，GSH具有较高的抗菌活性。观察到在向GSH水溶液中加入Na 2 WO 4时，GSH的抗菌活性显着降低。结果以提议的在水溶液中形成W-SG络合物为结论。

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来源
《African Journal of Biotechnology》 |2012年第45期|共7页
作者
Arshad Farid; Abdul Haleem Shah; Muhammad Ayaz; Adnan Amin Muhammad Yaseen; Hafeez Ullah; Fazal Haq;
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中图分类生物工程学（生物技术）;
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Glutathionesodium tungstateantibacterial activitystrains of bacteria;

机译：谷胱甘肽钨酸钠细菌的抗菌活性;

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Comparative study of biological activity of glutathione, sodium tungstate and glutathione-tungstate mixture

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