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首页> 外文期刊>African Journal of Laboratory Medicine >Late diagnosis of multidrug-resistant tuberculosis in a child at Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa: A case report
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Late diagnosis of multidrug-resistant tuberculosis in a child at Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa: A case report

机译：南非Ga-Rankuwa乔治·穆哈里（George Mukhari）学术医院的一名儿童的多药耐药结核病的晚期诊断：一例病例报告

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Introduction: South Africa has one of the top ten tuberculosis burdens in the world, only lagging behind countries with significantly larger populations. Increased awareness of extrapulmonary tuberculosis, specifically spinal tuberculosis, is necessary, because of the HIV epidemic. Case presentation: This report describes the case of a 9-year-old male patient who was suspected of having multidrug-resistant (MDR) tuberculosis, based on failure to recover clinically and radiologically after 6 months on first-line anti-tuberculosis treatment. Pus samples were sent to an accredited academic laboratory for histopathology, microscopy, culture, line-probe assay (MTBDR plus assay) and phenotypic MGIT 960 drug susceptibility tests. Second-line MDR tuberculosis treatment was introduced. Clinical, radiological, physical processes and more laboratory tests were conducted to document whether or not there was improvement in the patient. Management and outcome: After laboratory diagnosis of MDR tuberculosis, the patient was started on MDR tuberculosis treatment. The patient started improving remarkably after the introduction of anti-tuberculosis treatment and rehabilitation, although he also required surgery to stabilise the spine. Neurological improvement was observed in the patient and he fully recovered. Discussion: Although the diagnosis of spinal MDR tuberculosis may not be achieved easily by culture, the well-known gold standard method of tuberculosis diagnosis, it is of great importance to rapidly initiate an effective anti-tuberculosis treatment of drug-resistant strains to reduce the deformity of the spine.
机译：简介：南非是世界上十大结核病负担之一，仅落后于人口众多的国家。由于艾滋病毒的流行，有必要提高对肺外结核病特别是脊柱结核病的认识。病例介绍：该报告描述了一名9岁男性患者的病例，该患者因一线抗结核治疗6个月后未能在临床和放射学上康复而被怀疑患有多重耐药性（MDR）结核。脓液样本被送往认可的学术实验室进行组织病理学，显微镜检查，培养，线探针测定（MTBDR加测定）和表型MGIT 960药敏试验。介绍了二线耐多药结核病的治疗方法。进行了临床，放射学，物理过程和更多的实验室测试，以记录患者是否有所改善。处理和结果：实验室诊断耐多药结核病后，患者开始接受耐多药结核病治疗。引入抗结核治疗和康复后，患者开始明显改善，尽管他还需要进行手术以稳定脊柱。患者的神经功能得到改善，他完全康复。讨论：尽管通过培养（结核病诊断的金标准）难以轻易地诊断出脊柱耐多药结核病，但迅速启动有效的抗结核菌株的抗结核治疗对于减少结核病的发生具有重要意义。脊柱畸形。

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