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首页> 外文期刊>African Journal of Biotechnology >cDNA cloning and polymorphic domains of the major histocompatibility complex (MHC) class I in two Chinese native chicken breeds
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cDNA cloning and polymorphic domains of the major histocompatibility complex (MHC) class I in two Chinese native chicken breeds

机译：两个中国本土鸡品种的主要组织相容性复合体（MHC）I类的cDNA克隆和多态域

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摘要

Major histocompatibility complex (MHC) is a highly polymorphic gene and plays an important role in immune system for vertebrate. To understand the polymorphism character of domestic, we cloned 32 cDNAs of MHC class I?α?genes of two local chicken breeds in different areas of China. There were 112 variable amino acid residues in all five domains (leader peptide, α1, α2, α3 and TM/CY domains) of the putative α chain, and 76 of them were located in α1 and α2 domains. There were 23 to 25 polymorphic sites with high mutation frequency in α1 and α2 domains. Comparison of chicken with duck, human and mouse revealed that the two domains were highly similar among different species, and some highly polymorphic sites were located at the sites 9, 111(114), 113 (116) and 153 (156). Analysis of the phylogenetic tree indicated no relationship between the breeds and polymorphic alleles. All these results therefore indicate that MHC I class molecule of domestic chickens was more influenced by the pressure of common pathogens rather than geographic differences.
机译：主要组织相容性复合体（MHC）是高度多态的基因，在脊椎动物的免疫系统中起重要作用。为了了解家禽的多态性特征，我们在中国不同地区克隆了两个当地鸡品种的MHC I类α？α？基因的32个cDNA。在推定的α链的全部五个结构域（前导肽，α1，α2，α3和TM / CY结构域）中共有112个可变氨基酸残基，其中76个位于α1和α2结构域中。在α1和α2域中有23至25个具有高突变频率的多态性位点。鸡，鸭，人和小鼠的比较显示，两个域在不同物种之间高度相似，并且一些高度多态性位点位于位点9、111（114），113（116）和153（156）。系统发育树的分析表明，品种与多态性等位基因之间没有关系。因此，所有这些结果表明，家禽的MHC I类分子受普通病原体压力的影响更大，而不是地理差异。

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