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MicroRNA‐200 families and prognostic value in various carcinomas: A systematic review and meta‐analysis

机译：MicroRNA-200家族及其在各种癌症中的预后价值：系统评价和荟萃分析

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Background: Recently, some studies have showed that miR-200 families act asnovel biomarkers for the prediction of cancer outcomes.Aims: This meta-analysis was designed to investigate the associations betweenmiR-200 families and the prognosis of patients with various cancers.Materials & Methods: Eligible published databases including PubMed, Embase andChinese National Knowledge Infrastructure (CNKI) databases were searched for articles until October 18, 2016. We performed a meta-analysis by calculating pooledhazard ratios (HR) and 95% confidence intervals (CI). Data were extracted fromstudies comparing overall survival (OS), progression-free survival (PFS) or recurrence-free survival (RFS).Results: For OS, the pooled HR was 1.54 (95% CI: 1.01-2.33), showing that highmiR-200 family was clearly related to poor survival in various carcinomas, but nosignificantly association was found in PFS or RFS. Subgroup analysis indicated thatupregulated miR-200 family was linked to poor OS in Asians (HR = 2.19, 95% CI:1.27-3.78) but not in Caucasians (HR = 0.94, 95% CI: 0.46-1.91). Similarly, highmiR-200 expression could not clearly predict the relationship with PFS and RFS. Forcancer type, high miR-200 also predicted poor OS among lung cancer patients(HR = 3.09, 95% CI: 1.75-5.46). Besides, only elevated miR-200c of the miR-200family indicated a significantly poor OS (HR = 2.25, 95% CI: 1.39-3.64).Discussion: Aberrant expression of miRNAs played a crucial role in the area ofhuman carcinomas. Many studies have indicated that miRNAs are considered promising tumor biomarkers for prognosis and potential targets for clinical treatment. Wehave testified that high levels of miR-200 family expression (predominantly miR-200c) are significantly associated with poor survival and prognostic outcomes ofpatients with cancers, especially in lung cancer. However, no statistically significantresults were calculated for miR-200a/b and miR-429, and this might result from arelatively small number of articles about them. In other tumor models except lungcancer, our results indicated that high miR-200 family was not obviously associatedwith OS (Gastric or Colorectal cancer; Ovarian cancer; Others). In addition, someother records showed the opposite results, for they exhibited that upregulated miR-200 family level was linked to longer survival.
机译：背景：最近，一些研究表明miR-200家族可作为预测癌症结果的新生物标志物。目的：本荟萃分析旨在研究miR-200家族与各种癌症患者预后之间的关联。方法：检索包括PubMed，Embase和中国国家知识基础设施（CNKI）数据库在内的符合条件的已发布数据库，直到2016年10月18日。我们通过计算合并风险比（HR）和95％置信区间（CI）进行了荟萃分析。从比较总生存期（OS），无进展生存期（PFS）或无复发生存期（RFS）的研究中提取数据。结果：对于OS，合并的HR为1.54（95％CI：1.01-2.33），表明highmiR -200家族显然与各种癌症的不良生存有关，但在PFS或RFS中未发现明显关联。亚组分析表明，亚洲人（HR = 2.19，95％CI：1.27-3.78）中，miR-200家族上调与不良OS相关，而白种人（HR = 0.94，95％CI：0.46-1.91）与OS无关。同样，highmiR-200表达不能清楚地预测与PFS和RFS的关系。在癌症类型中，高miR-200也预测肺癌患者的OS较差（HR = 3.09，95％CI：1.75-5.46）。此外，只有miR-200家族中升高的miR-200c表示OS明显较差（HR = 2.25，95％CI：1.39-3.64）。讨论：miRNA的异常表达在人类癌症领域起着至关重要的作用。许多研究表明，miRNA被认为是有希望的预后肿瘤生物标志物和临床治疗的潜在靶标。我们已经证明，高水平的miR-200家族表达（主要是miR-200c）与癌症患者，尤其是肺癌患者的不良生存率和预后相关。但是，没有针对miR-200a / b和miR-429计算出统计学上显着的结果，这可能是由于有关它们的文章数量相对较少。在除肺癌以外的其他肿瘤模型中，我们的结果表明，高miR-200家族与OS（胃癌或结肠直肠癌;卵巢癌;其他）没有明显相关性。此外，其他一些记录显示了相反的结果，因为它们显示出miR-200家族水平上调与更长的生存期有关。

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