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首页> 外文期刊>Agriculture, Forestry and Fisheries >Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells
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Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells

机译：章鱼（Enterocopus dofleini）肝提取物在HepG2细胞中显示降低甘油三酸酯的作用

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Fatty liver disease is characterized by the accumulation of triglycerides and other fats in the liver cells and is believed to be a risk of later chronic liver disease. Diet is one of the key ways to treat fatty liver disease. Octopus (Enterocopus dofleini) liver is eaten in some regions in Japan, but mostly discarded. For utilization of octopus liver, the lipidlowering effect of octopus (Enterocopus dofleini) liver extract was investigated using human hepatoma cells (HepG2 cells). The present study showed that the octopus liver extract reduced the triglyceride content, but not cholesterol content, in HepG2 cells. Treatment with the octopus liver extract increased the mRNA expression of genes for peroxisome proliferator-activated receptor (PPAR)-α, medium chain acyl-CoA dehydrogenase (MCAD), and acyl-CoA oxidase (ACO) associated with β-oxidation. On the contrary, the extract did not change the mRNA expression of genes for sterol regulatory element-binding protein (SREBP)-1, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD)-1, and peroxisome proliferator-activated receptor (PPAR)-g involved in fatty acid synthesis. These results suggest that octopus liver extract may decrease the triglyceride level in HepG2 cells by promoting β-oxidation, suggestive of its usefulness as a food for lowering triglycerides in liver.
机译：脂肪性肝病的特征是肝细胞中甘油三酸酯和其他脂肪的积累，并被认为可能导致以后发生慢性肝病。饮食是治疗脂肪肝的关键方法之一。章鱼（Enterocopus dofleini）肝脏在日本某些地区被食用，但大部分被丢弃。为了利用章鱼肝脏，使用人肝癌细胞（HepG2细胞）研究了章鱼（Enterocopus dofleini）肝脏提取物的降脂作用。本研究表明，章鱼肝提取物可降低HepG2细胞中的甘油三酸酯含量，但不能降低胆固醇含量。用章鱼肝提取物治疗可增加过氧化物酶体增殖物激活受体（PPAR）-α，中链酰基辅酶A脱氢酶（MCAD）和与β氧化相关的酰基辅酶A氧化酶（ACO）的基因的mRNA表达。相反，提取物未改变固醇调节元件结合蛋白（SREBP）-1，乙酰辅酶A羧化酶（ACC），脂肪酸合酶（FAS），硬脂酰辅酶A去饱和酶（SCD）-的基因的mRNA表达。 1和过氧化物酶体增殖物激活受体（PPAR）-g参与脂肪酸合成。这些结果表明，章鱼肝提取物可通过促进β-氧化来降低HepG2细胞中的甘油三酸酯水平，表明其可用作降低肝脏中甘油三酸酯的食物。

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