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Associations of CYP1A1 gene polymorphisms and risk of breast cancer in Indian women: a meta-analysis

机译：CYP1A1 基因多态性与印度女性乳腺癌风险的关联：一项荟萃分析

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Reported associations of CYP1A1 polymorphisms with breast cancer have been inconsistent. In this meta-analysis examining breast cancer associations of three CYP1A1 polymorphisms (M1, M2 and M4) among Indian women may yield information that may be of clinical and epidemiological use for this particular demography. We searched MEDLINE using PubMed and Embase for association studies. From seven published case-control studies, we estimated overall associations and applied subgroup analysis to explore differential effects. All three polymorphisms exhibited overall increased risk, significant in M1 (OR 1.61-1.65, p = 0.04) and M4 (OR 2.02-3.92, p = 0.02-0.04). Differential effects were observed only in the M1 polymorphism where M1 effects were significant in South Indians (OR 2.20-4.34, p < 0.0001) but not the North population, who were at reduced risk (OR 0.64-0.77, p = 0.03-0.55). These populations were not materially different in regard to M2 and M4 as did the women stratified by menopausal status. In this meta-analysis, M1 and M4 effects may render Indian women susceptible, but may be limited by heterogeneity of the studies. Differential effects of the M1 polymorphism in breast cancer render South Indians susceptible compared to those in the North.
机译：CYP1A1基因多态性与乳腺癌的相关报道不一致。在这项荟萃分析中，印度妇女中三种CYP1A1多态性（M1，M2和M4）与乳腺癌的关联性可能会得出可能对该特定人口统计学有临床和流行病学意义的信息。我们使用PubMed和Embase在MEDLINE中进行了关联研究。从七项已发表的病例对照研究中，我们估计了整体关联性，并应用了亚组分析来探讨不同的影响。所有这三种多态性均显示总体风险增加，在M1（OR 1.61-1.65，p = 0.04）和M4（OR 2.02-3.92，p = 0.02-0.04）中显着。仅在M1多态性中观察到差异作用，其中M1效应在南印度人中显着（OR 2.20-4.34，p <0.0001），而北部人群则没有，后者风险降低（OR 0.64-0.77，p = 0.03-0.55） 。这些人群在M2和M4方面没有实质性差异，与按绝经状态分层的女性没有太大差异。在这项荟萃分析中，M1和M4效应可能使印度妇女易感，但可能受研究异质性的限制。与北部地区相比，M1多态性在乳腺癌中的差异作用使南印度人易感。

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